| IED ID | IndEnz0002015298 |
| Enzyme Type ID | protease015298 |
| Protein Name |
Intercellular adhesion molecule 2 ICAM-2 CD antigen CD102 |
| Gene Name | ICAM2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSSFGYRTLTVALFTLICCPGSDEKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQMVIIVTVVSVLLSLFVTSVLLCFIFGQHLRQQRMGTYGVRAAWRRLPQAFRP |
| Enzyme Length | 275 |
| Uniprot Accession Number | P13598 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (15); Chain (1); Disulfide bond (3); Domain (2); Glycosylation (6); Helix (3); Natural variant (3); Region (1); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | 3D-structure;Cell adhesion;Cell projection;Direct protein sequencing;Disulfide bond;Glycoprotein;Immunoglobulin domain;Membrane;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P35330}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P35330}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000269|PubMed:19892738 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1ZXQ; |
| Mapped Pubmed ID | 11017109; 11857637; 12097408; 14970226; 15545280; 15548573; 16857989; 16987074; 17059578; 17609265; 18155766; 18768213; 18842965; 18978946; 19175829; 19423540; 19524015; 20237496; 20406964; 20438785; 20711500; 20955708; 21656680; 22190034; 22645275; 23591197; 23714211; 24457076; 24474251; 24704826; 26377944; 26641849; 27556181; 27592383; 29671117; 34484188; 8995416; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,654 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |