IED Industry Enzyme Database

Detail Information for IndEnz0002015341
IED ID IndEnz0002015341
Enzyme Type ID protease015341
Protein Name Eukaryotic translation initiation factor 4 gamma 1
eIF-4-gamma 1
eIF-4G 1
eIF-4G1
p220
Gene Name EIF4G1 EIF4F EIF4G EIF4GI
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Enzyme Length 1599
Uniprot Accession Number Q04637
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (6); Chain (1); Compositional bias (15); Domain (3); Erroneous initiation (2); Frameshift (1); Helix (4); Initiator methionine (1); Modified residue (33); Mutagenesis (21); Natural variant (17); Region (12); Sequence caution (1); Sequence conflict (25); Site (2); Turn (2)
Keywords 3D-structure;Acetylation;Alternative initiation;Alternative splicing;Cytoplasm;Disease variant;Host-virus interaction;Initiation factor;Methylation;Neurodegeneration;Parkinson disease;Parkinsonism;Phosphoprotein;Protein biosynthesis;RNA-binding;Reference proteome;Translation regulation;Translational shunt
Interact With O00571; O75822; P60842; P06730; Itself; Q14103-4; P11940; Q9BWF3-1; Q9J0X9; P60842; Q9NQ94; Q8N5M1; Q2TAC2-2; P55273; Q99828; P56545-3; Q86UW9; Q9H0I2; P51116; Q15323; O76011; Q96HA8; Q9UBV8; Q96GM5
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm, Stress granule {ECO:0000269|PubMed:22872150}.
Modified Residue MOD_RES 15; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q6NZJ6"; MOD_RES 73; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 110; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 207; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163"; MOD_RES 223; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:18669648"; MOD_RES 314; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:24275569"; MOD_RES 602; /note="N6-acetyllysine"; /evidence="ECO:0000250|UniProtKB:Q6NZJ6"; MOD_RES 647; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163"; MOD_RES 685; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 694; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 1028; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1032; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 1042; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES 1077; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 1092; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1095; /note="N6-acetyllysine"; /evidence="ECO:0007744|PubMed:19608861"; MOD_RES 1145; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1147; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1185; /note="Phosphoserine; by PKC/PRKCA"; /evidence="ECO:0000269|PubMed:21576361, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1187; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1194; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 1209; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1211; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692"; MOD_RES 1231; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES 1238; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 1596; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"; MOD_RES Q04637-4:2; /note="N-acetylmethionine"; /evidence="ECO:0007744|PubMed:22814378"; MOD_RES Q04637-7:489; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES Q04637-7:498; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES Q04637-7:509; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES Q04637-8:685; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES Q04637-8:694; /note="Omega-N-methylarginine"; /evidence="ECO:0007744|PubMed:24129315"; MOD_RES Q04637-8:705; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"
Post Translational Modification PTM: Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1. {ECO:0000269|PubMed:21576361}.; PTM: Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. {ECO:0000269|PubMed:11034318, ECO:0000269|PubMed:8396129, ECO:0000269|PubMed:9755863}.
Signal Peptide
Structure 3D Electron microscopy (1); X-ray crystallography (9)
Cross Reference PDB 1LJ2; 1UG3; 2W97; 4AZA; 4F02; 5EHC; 5EI3; 5EIR; 5T46; 6ZMW;
Mapped Pubmed ID 10205060; 10364207; 10559216; 10637334; 10659855; 10859165; 10882133; 11018020; 11283721; 11331269; 11408474; 11532962; 11544179; 11546874; 11551508; 11821405; 11842200; 11866104; 11889047; 12054647; 12136087; 12239292; 12417715; 12505164; 12554878; 12581158; 12588972; 12718880; 12819195; 12832468; 1355481; 14527413; 14583602; 14592777; 14636577; 14742663; 14749774; 14973490; 15034551; 15047801; 15128869; 15153109; 15161933; 15193258; 15220445; 15231748; 15234964; 15314020; 15361857; 15452223; 15475613; 15546618; 15567442; 15721257; 15755734; 15885108; 15961545; 16141059; 16156639; 16169070; 16186820; 16209946; 16281055; 16284618; 16412378; 16452507; 16556936; 16601204; 16622410; 16698542; 16739988; 16766523; 16932749; 16982693; 17052452; 17053788; 17130132; 17245413; 17266347; 17289916; 17290396; 17352659; 17353931; 17363904; 17469741; 17595167; 17601486; 17803942; 17893241; 18005740; 18066079; 18230761; 18250159; 18256688; 18296639; 18423202; 18426977; 18447580; 18447585; 18524595; 1856230; 18573886; 18593934; 18614538; 18625844; 18657639; 18847512; 18974281; 19060897; 19114555; 19150429; 19203580; 19239894; 19359157; 19417104; 19440045; 19478851; 19503078; 19525934; 19556969; 19558367; 19716330; 19769989; 19804365; 19850929; 19859661; 19909264; 19956697; 20023408; 20028737; 20053821; 20360068; 20398343; 20479275; 20691628; 20817927; 20930030; 21029861; 21145460; 21182205; 21377182; 21419344; 21454508; 21840318; 21900206; 21964297; 21988832; 22178476; 22280895; 22509910; 22561553; 22623428; 22658323; 22707335; 22772876; 22909319; 23023399; 23041282; 23085078; 23092605; 23094039; 23112151; 23124435; 23209657; 23234702; 23261770; 23263986; 23408866; 23409027; 23490116; 23562511; 23606334; 23617574; 23726718; 23746841; 23901100; 23902751; 23974796; 24063684; 24080171; 24092755; 24189400; 24248602; 24704100; 24815186; 24843127; 24854799; 24979134; 25049413; 25255371; 25368108; 25480299; 25593313; 25609649; 25717031; 25738462; 26022768; 26170285; 26300542; 26490695; 26496610; 26951381; 27003362; 27162083; 27501049; 27525590; 27592390; 27773676; 29142127; 291969; 29717265; 29718834; 29748619; 30012863; 30012864; 30127386; 31268247; 32421011; 32571876; 32659970; 32883864; 32941651; 33239198; 33523588; 33539648; 33693953; 429297; 592399; 641056; 6853548; 7000367; 8449919; 8943342; 9045610; 9099687; 9732867;
Motif
Gene Encoded By
Mass 175,491
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda