| IED ID |
IndEnz0002015369 |
| Enzyme Type ID |
protease015369 |
| Protein Name |
Probable insulin-like peptide beta-type 5
|
| Gene Name |
ins-6 ZK84.6 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MNSVFTIIFVLCALQVAASFRQSFGPSMSEESASMQLLRELQHNMMESAHRPMPRARRVPAPGETRACGRKLISLVMAVCGDLCNPQEGKDIATECCGNQCSDDYIRSACCP |
| Enzyme Length |
112 |
| Uniprot Accession Number |
P56174 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions (PubMed:23665919). Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions (PubMed:24671950). Acts on AWC sensory neurons to regulate high salt chemotaxis responses (PubMed:24013594). {ECO:0000269|PubMed:23665919, ECO:0000269|PubMed:24013594, ECO:0000269|PubMed:24671950}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (1); Chain (1); Disulfide bond (4); Helix (3); Mutagenesis (2); Propeptide (1); Signal peptide (1); Turn (1) |
| Keywords |
3D-structure;Cleavage on pair of basic residues;Disulfide bond;Hormone;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: May be processed by serine endoprotease bli-4. {ECO:0000305|PubMed:24013594}. |
| Signal Peptide |
SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D |
NMR spectroscopy (1) |
| Cross Reference PDB |
2KJI;
|
| Mapped Pubmed ID |
11274053;
12654724;
21343369;
22560298;
23395381;
23539137;
23800452;
25128585;
25487147;
27129311;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
12,273 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|