| IED ID | IndEnz0002015400 |
| Enzyme Type ID | protease015400 |
| Protein Name |
Heparin cofactor 2 Heparin cofactor II HC-II Protease inhibitor leuserpin-2 Serpin D1 |
| Gene Name | Serpind1 Hcf2 Hcii |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MKHPLCTLLSLITFMCIGSKGLAEQLTNENLTTSFLPANFHKENTVTNDWIPEGEEDEDYLDLEKLLGEDDDYIYIIDAVSPTDSESSAGNILQLFQGKSRIQRLNILNAKFAFNLYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHFRDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQEANFPDPAFISKANNHILKLTKGLIKEALENIDPATQMLILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISDQRIAIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNPAKS |
| Enzyme Length | 478 |
| Uniprot Accession Number | P49182 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (4); Modified residue (2); Region (2); Repeat (2); Signal peptide (1); Site (1) |
| Keywords | Blood coagulation;Direct protein sequencing;Glycoprotein;Hemostasis;Heparin-binding;Protease inhibitor;Reference proteome;Repeat;Serine protease inhibitor;Signal;Sulfation |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 60; /note=Sulfotyrosine; /evidence=ECO:0000250; MOD_RES 73; /note=Sulfotyrosine; /evidence=ECO:0000250 |
| Post Translational Modification | PTM: N-glycosylated; different glycan composition appears to lead to two forms of this protein (68 and 72 kDa). {ECO:0000269|PubMed:16944957}. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000269|PubMed:7908224 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10095113; 10337614; 10963672; 11414760; 11805133; 12024037; 15315969; 16497528; 17549254; 17878401; 18000606; 18281504; 21267068; 21677750; 22904320; 22985540; 23656734; 28502917; 30870413; 9405660; 9565648; 9615230; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,497 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |