| IED ID | IndEnz0002015410 |
| Enzyme Type ID | protease015410 |
| Protein Name |
Hirudin variant-1 Hirudin-1 Hirudin-I Lepirudin |
| Gene Name | |
| Organism | Hirudo medicinalis (Medicinal leech) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Annelida Clitellata Hirudinea (leeches) Hirudinida Hirudiniformes Hirudinidae Hirudo Hirudo medicinalis (Medicinal leech) |
| Enzyme Sequence | VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ |
| Enzyme Length | 65 |
| Uniprot Accession Number | P01050 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. {ECO:0000269|PubMed:17585879}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (6); Chain (1); Disulfide bond (3); Glycosylation (1); Helix (1); Modified residue (1); Mutagenesis (19); Region (3) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Pharmaceutical;Protease inhibitor;Secreted;Serine protease inhibitor;Sulfation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 63; /note="Sulfotyrosine"; /evidence="ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938" |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (6); X-ray crystallography (68) |
| Cross Reference PDB | 1AD8; 1AE8; 1AFE; 1AHT; 1AI8; 1AWF; 1AY6; 1BA8; 1BB0; 1BCU; 1CA8; 1D3D; 1D3P; 1D3Q; 1D3T; 1D4P; 1H8D; 1H8I; 1HIC; 1HRT; 1HXE; 1HXF; 1NO9; 1QHR; 1QJ1; 1QJ6; 1QJ7; 1TMT; 1TMU; 1UMA; 1WBG; 2HIR; 2JOO; 2PW8; 2UUF; 2UUJ; 2UUK; 2V3O; 2ZC9; 2ZDA; 2ZDV; 2ZF0; 2ZFF; 2ZFP; 2ZGB; 2ZGX; 2ZHQ; 2ZI2; 2ZIQ; 2ZNK; 2ZO3; 3D49; 3DHK; 3DT0; 3DUX; 3EGK; 3EQ0; 3LDX; 3UTU; 4AX9; 4BAH; 4BAK; 4BAM; 4BAN; 4BAQ; 4HIR; 4LXB; 4MLF; 4YES; 5HIR; 6HIR; 7A0D; 7A0E; 7A0F; |
| Mapped Pubmed ID | 10387040; 10739244; 11493008; 12885234; 1304349; 15152000; 15658854; 17642517; 17901324; 17955562; 19520086; 20156458; 22907907; 23290007; 24113284; 24175584; 26005532; 7574675; 7966150; 8367461; 8605148; 8637015; 9033393; 9108691; 9217260; 9232642; 9559654; 9578548; 9724521; |
| Motif | |
| Gene Encoded By | |
| Mass | 6,970 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |