| IED ID | IndEnz0002015441 |
| Enzyme Type ID | protease015441 |
| Protein Name |
Insulin-degrading enzyme homolog EC 3.4.24.- Insulin protease homolog Insulinase homolog Insulysin homolog |
| Gene Name | DDB_G0287851 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MVANEQQQQQQEEERKEVKLIQSPNDNNKYRYVKLKNGLEVVLVSDETTDQSSCCLSINIGSLCNPREIEGLAHFLEHMLFLGTEKFPVEKEFVNFIYLNGGSYNGTTSPNKTNYYFTVNQESFEEALDRFSSFFISPLMNEDAVNRELNAVDSEHNNNMQKDFWRMDRIVNDQFEGHPMSMFFTGDSSTLKRDDIREKVVEFYQRYYSANLMKVCIFGRESLDQLEEYANKYFLPIVNKDVKVPKLPPLAITSKSIMIEAEPTQDMDLLKFVFPIPDEKLCFSKNYKNASASILSHILGHECQGSLFSVLFNKDYAFSLSISSNSFYENMNKIEIQIHLTKTGLENVDEVIALLFQSFEFDTPEYFFTEKKLLSEINWKSFQKSAPASTTQAITSNLFRVERPEETLKYNNFLEQFAPEKIKEIQSYLRPDNMICLFYSSTKFKGKTTEIEPHYKIKFNKRYIEQSDFDKWKSFPKNTNLFLPKENPFLPIDTTIKAPQDHSIHIPKEVYNNNGVKVYHSLDHRFNSPKARVNIRFELTSYGNNQSMVMWNLLKKSLKEVLNEKILYYLSVLDFSMKLQILTTHVELQCYCFNDIIFTALGKVFDFLMNLDLNDMQFKRIKEKVAKRFLSSHYLSPYQISMRHLSLHNFNCNSMLLDKQEYLKKVTKSEFLNYFKSLFSYINFSAMVVGNASIEDACAFGEKLNSFSNRNSACPGEVFKLARVNLPSNTITHQREFLYDTNQTNCSSSISFLIGQFNRKTYATTLVICSILGSAYFEELRTKKQFGYVVNCAQDCTGNAISMRCIVQSHTKTPEEIFDATMEFFVGFEKTLDYFKTSPSDFKDLIENCQKQNTVKQQSNSAQSSLYWSFFTFCGDFEFEKKKYEDIGKITFDDVKQYYLDHLSPNTANLRIFAAHCYPQSYQIPDEVKPFGNVKVNLLRKYEHDNFKENHGYLSSKVNLQK |
| Enzyme Length | 962 |
| Uniprot Accession Number | Q54JQ2 |
| Absorption | |
| Active Site | ACT_SITE 77; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3); Region (1) |
| Keywords | Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 112,074 |
| Kinetics | |
| Metal Binding | METAL 74; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 78; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 155; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096 |
| Rhea ID | |
| Cross Reference Brenda |