| IED ID |
IndEnz0002015444 |
| Enzyme Type ID |
protease015444 |
| Protein Name |
Metalloproteinase inhibitor
|
| Gene Name |
smpI |
| Organism |
Streptomyces nigrescens |
| Taxonomic Lineage |
cellular organisms
Bacteria
Terrabacteria group
Actinobacteria
Actinomycetia (high G+C Gram-positive bacteria)
Streptomycetales
Streptomycetaceae
Streptomyces
Streptomyces nigrescens
|
| Enzyme Sequence |
MVRKRALGLAGSALTLVLGAVGFTAPAQAAPSCPAGSLCTYSGTGLSGARTVIPASDMEKAGTDGVKLPASARSFANGTHFTLRYGPARKVTCVRFPCYQYATVGKVAPGAQLRSLPSPGATVTVGQDLGD |
| Enzyme Length |
131 |
| Uniprot Accession Number |
P01077 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Inhibits microbial metallo-proteinases, such as thermolysin, but not serine, thiol, or carboxyl proteinases. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (8); Chain (1); Disulfide bond (2); Helix (1); Signal peptide (1); Turn (1) |
| Keywords |
3D-structure;Direct protein sequencing;Disulfide bond;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..29; /evidence=ECO:0000269|PubMed:3888972 |
| Structure 3D |
NMR spectroscopy (1) |
| Cross Reference PDB |
1BHU;
|
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
13,186 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|