| IED ID | IndEnz0002015463 |
| Enzyme Type ID | protease015463 |
| Protein Name |
Mycosin-1 EC 3.4.21.- MycP1 protease |
| Gene Name | mycP1 MSMEG_0083 MSMEI_0081 |
| Organism | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Corynebacteriales Mycobacteriaceae Mycolicibacterium Mycolicibacterium smegmatis (Mycobacterium smegmatis) Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) |
| Enzyme Sequence | MQRVAVMVLAVLLALFSAPPAWAIDPPVIDAGAVPPDETGPDQPTEQRKICATPTVMPNSNFADRPWANDYLRIQEAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDAAGNGMSDCDAHGTMTAAIIGGRPSPTDGFVGMAPDVRLLSLRQTSVAFQPKGARQDPNDPNTTQTAGSIRSLARSVVHAANLGAQVINISEAACYKVTRRIDETSLGAAINYAVNVKGAVIVVAAGNTGQDCSQNPPPDPSVPSDPRGWREVQTIVSPAWYDPLVLTVGSIGQNGQPSNFSMSGPWVGAAAPGENLTSLGYDGQPVNATPGEDGPVPLNGTSFSAAYVSGLAALVKQRFPDLTPAQIINRITATARHPGGGVDNYVGAGVIDPVAALTWEIPDGPEKAPFRVKEVPPPVYIPPPDRGPITAVVIAGATLAFALGIGALARRALRRKQ |
| Enzyme Length | 449 |
| Uniprot Accession Number | A0QNL1 |
| Absorption | |
| Active Site | ACT_SITE 92; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01240, ECO:0000305|PubMed:23620593, ECO:0000305|PubMed:24248472"; ACT_SITE 123; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01240, ECO:0000305|PubMed:23620593, ECO:0000305|PubMed:24248472"; ACT_SITE 334; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01240, ECO:0000305|PubMed:23620593, ECO:0000305|PubMed:24248472" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. {ECO:0000269|PubMed:20227664, ECO:0000269|PubMed:23620593}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (20); Chain (1); Disulfide bond (2); Domain (1); Helix (12); Mutagenesis (1); Region (2); Signal peptide (1); Transmembrane (1); Turn (3) |
| Keywords | 3D-structure;Cell membrane;Disulfide bond;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O05461}; Single-pass membrane protein {ECO:0000255}. Note=Cell wall-associated. {ECO:0000250|UniProtKB:O05461}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 4J94; 4KB5; 4KPG; 4M1Z; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,454 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |