| IED ID | IndEnz0002015469 |
| Enzyme Type ID | protease015469 |
| Protein Name |
Proton myo-inositol cotransporter H + -myo-inositol cotransporter Hmit H + -myo-inositol symporter Solute carrier family 2 member 13 |
| Gene Name | SLC2A13 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSRKASENVEYTLRSLSSLMGERRRKQPEPDAASAAGECSLLAAAESSTSLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVSPRITFKPIAPSGQNATCTRYSYCNECMLDPDCGFCYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDVE |
| Enzyme Length | 648 |
| Uniprot Accession Number | Q96QE2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in); Xref=Rhea:RHEA:60364, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268; Evidence={ECO:0000269|PubMed:11500374}; |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374). {ECO:0000269|PubMed:11500374}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (3); Glycosylation (3); Modified residue (5); Topological domain (13); Transmembrane (12) |
| Keywords | Cell membrane;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | P78329; Q96CV9; Q04941; Q9NPQ8-4 |
| Induction | INDUCTION: Induced by hyperosmotic stress. {ECO:0000269|PubMed:21679696}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11500374}; Multi-pass membrane protein {ECO:0000269|PubMed:11500374}. |
| Modified Residue | MOD_RES 6; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q3UHK1"; MOD_RES 47; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q3UHK1"; MOD_RES 50; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:Q3UHK1"; MOD_RES 640; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231"; MOD_RES 645; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569" |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000269|PubMed:11500374}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 19473719; 19607714; 20379614; 26094765; 31689868; 31918632; |
| Motif | |
| Gene Encoded By | |
| Mass | 70,371 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:60364 |
| Cross Reference Brenda |