| IED ID | IndEnz0002015477 |
| Enzyme Type ID | protease015477 |
| Protein Name |
Zinc metalloproteinase nas-12 EC 3.4.24.- Nematode astacin 12 |
| Gene Name | nas-12 C24F3.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MLYIPQFSIYFCLGYLLLFCKISNAVKQSWEINQELITEANKEHTVFGDMLLTPAQLIRYENSKDSDLSIRGVSIKGSSMNRWSNNIVPYVISPQYSPAQKQILVSSLRYFERVSCFKFVERTTQNDYLFIVPLDGCYSYVGKIGGRQTLSLAADCIADYIIWHEMMHAIGFEHEHQRPDRDSFIRVDYANVIPGQMINFDKLKTSHVEYPDIYDFKSIMHYDGYAFGRVDTARRVRLATMTPLKPGVTLEDNMKFTATDIEKLNRLGQCGARGGQYSNQGVVASTCQDVATAVSCEGNRRRGMCKNPFYKQMMIKSCQKTCRLCSYTRMIDEDDDLTPNTTVKSVKCEDKHPRCDIYSHNGFCTLPFYDDVRYQLCAKTCNLC |
| Enzyme Length | 384 |
| Uniprot Accession Number | Q9XTD6 |
| Absorption | |
| Active Site | ACT_SITE 165; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:P07584}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (8); Domain (3); Glycosylation (1); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15338614; 17164286; 17850180; 19343510; 21367940; 22347378; 22560298; 22759833; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,082 |
| Kinetics | |
| Metal Binding | METAL 164; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 168; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 174; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |