| IED ID | IndEnz0002015480 |
| Enzyme Type ID | protease015480 |
| Protein Name |
Zinc metalloproteinase nas-15 EC 3.4.24.- Nematode astacin 15 |
| Gene Name | nas-15 T04G9.2 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MREYVLIFLVAPVFAAILGPYDIPPELPPLNDENFFDRSHSEYETVLTPEDFELGTRITAAMAHDNGDDIWDSDAMYSKDRFEGDIANDNLNASTAELFANGGSGKSEDGKWYNAIKNRLQLWPEGRIPYTISSQYSSYSRSLIAASMQEYASHTCIRWVPKEAADVNYVHIYPDRGCYSMVGKMGGKQSLSLGSGCIQKGIILHELMHAVGFFHEQSRTDRDDHITIMWNNIQAGMQGQFEKYGHGTIQSLGTGYDYGSIMHYGTKAFSRNGQPTMIPKKNGATIGQRNGFSKVDKFKINTLYGCPVEGEKPTTSAPTSGPIVITVKPVVITTGKPPVIQTVSPAVPLKPSECRNLRGDCDDLAKQGWCIRNPGWMRANCPISCGMCIPTKETQKPYVQTTTQAATTTARPQKPVTQPIQPLPPVPPLPPTTPEDCEDLRVDCLVLVSQRYCKISQNFMKSYCAKSCGFCFKPPPTEIPDNRPTVVTTRPLVTLPPAVIRSRSPAPPVSTTTKAAPTTSTTSAAPYSPTPLPSECSDRKHFCSHWKSAGFCEGIFMNYMKKNCPASCGLC |
| Enzyme Length | 571 |
| Uniprot Accession Number | P55115 |
| Absorption | |
| Active Site | ACT_SITE 206; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:P07584}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (1); Disulfide bond (11); Domain (4); Glycosylation (1); Metal binding (3); Propeptide (1); Region (2); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 15338614; 17850180; 21177967; 22267497; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 62,831 |
| Kinetics | |
| Metal Binding | METAL 205; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 209; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 215; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |