| IED ID | IndEnz0002015483 |
| Enzyme Type ID | protease015483 |
| Protein Name |
Zinc metalloproteinase nas-18 EC 3.4.24.21 Nematode astacin 18 |
| Gene Name | nas-18 K03B8.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MCASCLHNANAASFLMETFSRHRLNFICIGKMNIFYNVTSLDNKYSFHNPSAPVPHSSHALSSRQAHFTSFRAPVAPPSRPRRSQLPSSAKLLYCFDSSFSTEKRELMLFSMNFISSQTCVTFEENCSIPNRVQLVNGKGCSSYIGMNNIVQHLTFNDTCIDFGTAVHELMHALGVIHTHSRLDRDNFLNINLTNVSKEMMHNYAIFNQSTNVVPYEYGSTMHYYANISTMFPKKSEYSATLGIGRVTFYDMVILNTAYNCKCPNELLCGNGGYTNPSKCSECICPLGYGGVLCDRPSLIGKDTGLPLEVKDKIIEVKVVGIDNFFSYPTCLINGLEIKYMGDPRITNPIYCSADLINGKSFRSKLNPLLMNIHTLFGKNKVTFHYRYVTERLSGYNKTTNGYDNYEYYD |
| Enzyme Length | 410 |
| Uniprot Accession Number | Q21179 |
| Absorption | |
| Active Site | ACT_SITE 169; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.; EC=3.4.24.21; Evidence={ECO:0000250|UniProtKB:P07584}; |
| DNA Binding | |
| EC Number | 3.4.24.21 |
| Enzyme Function | FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:P07584}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (4); Domain (2); Glycosylation (8); Metal binding (3); Propeptide (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12529643; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,271 |
| Kinetics | |
| Metal Binding | METAL 168; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 172; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 178; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |