| IED ID | IndEnz0002015487 |
| Enzyme Type ID | protease015487 |
| Protein Name |
Zinc metalloproteinase nas-22 EC 3.4.24.- Nematode astacin 22 |
| Gene Name | nas-22 T11F9.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKSFFILLSILQECYGKDIVARIGGRNVAEKIGGARHRRQVLIRGSDEERRHKWFNNTVHYYFYEENFDFTVKESILRAMELISNHTCIKFSTEPSEKSIRMESDSTTIACYAEIGQVRENQLFSFNSDCYSAGVAVHELIHSLGFIHAHQRSDRDQYLEFKKNLDELNQTYQEQYKIWEYQEILVPYDVGSVMQYPNEEDEEYYPVRKYRTMANTMGSAIVAFYDYLMINKYYECSCANNLSCKNHGYPNPSNCSQCNCPYGFGGADCSQRAEPGATFQATETWQNVTISLDAGYRYLENNQKLPQVDFIYQFLWIMAPANKTTQIRVEKFVEGKCLPGCIRGGVEIKTNEDPRLTSPRLCCEETS |
| Enzyme Length | 367 |
| Uniprot Accession Number | Q22398 |
| Absorption | |
| Active Site | ACT_SITE 139; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:P07584}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (4); Domain (2); Glycosylation (7); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 12097347; 15338614; 17850180; 20439776; 21367940; 22267497; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,514 |
| Kinetics | |
| Metal Binding | METAL 138; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 142; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 148; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |