| IED ID | IndEnz0002015493 |
| Enzyme Type ID | protease015493 |
| Protein Name |
Zinc metalloproteinase nas-28 EC 3.4.24.- Nematode astacin 28 |
| Gene Name | nas-28 F42A10.8 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MFFPVVFFIPFVLGAPTQKALEKILVDNNPDSVTNREKIRGIIDKAFENRVPRVQGRQGVAPPVTFAALNYGPKNNQTKKFEELNQDINEYTFESDIMLNEKQAKHIATAIENGNYRSKRQAIVDTTNFWSVSVPIFYQFDTKLSATNIANVRKAIQFWNDNSCLSFKEDNNAKNRLFLSSAGGCWSYVGKQVDMPYQMVSVGPNCDTFGTATHELMHAIGFWHQQSRADRDNYVYVDFSNIIPSQAYNFQKMAVDQAQLLNLPYDYGSVMQYYPYAFAVDSSKYTILAKENGFQNSMGQREAPAFSDIIGVNKLYNCTSQCKIQMKCSNCGITDSRNCNQCKCPRYFTGASCDSLPSGTAPNCNGAVLQATSSWETFDAKAGDPSSFSSSTDNSTNCYWHIKAPEGQQIEFKMTKTPLAAICMQECPWQSIEVNLGKFDLFGMITCCDTILNQVFTSELNMIALRGIIRYNQLTFSIQYRAVPSSKPASTNACLNQ |
| Enzyme Length | 497 |
| Uniprot Accession Number | P98061 |
| Absorption | |
| Active Site | ACT_SITE 215; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:A8Q2D1}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (7); Domain (3); Frameshift (1); Glycosylation (3); Metal binding (3); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Cleavage on pair of basic residues;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..14; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20109220; 21177967; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 55,786 |
| Kinetics | |
| Metal Binding | METAL 214; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 218; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 224; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |