| IED ID | IndEnz0002015503 |
| Enzyme Type ID | protease015503 |
| Protein Name |
Zinc metalloproteinase dpy-31 EC 3.4.24.- Nematode astacin 35 Procollagen C-proteinase |
| Gene Name | dpy-31 nas-35 |
| Organism | Haemonchus contortus (Barber pole worm) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Strongylida Trichostrongyloidea Haemonchidae Haemonchus Haemonchus contortus (Barber pole worm) |
| Enzyme Sequence | MSLLRSASLLLVVVTAALPPCTLGYSLHDGSRLDDVIAEFTAERRPRRLATPAQRRLMGLTEEQHKTVQFYLDKLRELGNRRHPESYNKDSPKNEAYKWRKQMRDDLKTELLNPEKYGRHFEGDIILFPEQAKQIYENALKTGQRRVKRKFIGSDLRRWDPTRPIIYSFDGSHTSREQRIIELALEHRHNITCLNFVRNDNANKGNRIVFTDVDGCASNVGRHPLGEEQLVSLAPECIRLGVIAHEVAHALGFWHEQSRPDRDQFVNVRWENIDKDSKGQFLKEDPDDVDNAGVPYDYGSIMHYRSKAFSRYDDLYTISTFVTDYQKTIGQRDQLSFNDIRLMNKIYCSNVCSRKLPCQRGGYTDPRRCDRCRCPDGFTGQFCEQVMPGYGAVCGGRIQVNSGWTRFSSPGYPREFKEGQECSWLLVAPPGQVVEMQFIGEFEMYCKVRHSLCMDYVEVRNSTDFANTGMRYCCYGTPSTSIRSATTDLVVLFRSFYRGGRGFEARARALPANGQWASWTPWTPCTASCGACGSRMRTRVCPHGACPC |
| Enzyme Length | 548 |
| Uniprot Accession Number | D5FM34 |
| Absorption | |
| Active Site | ACT_SITE 246; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease which cleaves the carboxyl terminus of procollagens to mature collagens. Probably involved in cuticular collagen maturation. {ECO:0000269|PubMed:19883650}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (1); Chain (1); Disulfide bond (8); Domain (4); Glycosylation (2); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Alternative splicing;Cleavage on pair of basic residues;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 62,762 |
| Kinetics | |
| Metal Binding | METAL 245; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 249; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 255; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.21; |