| IED ID | IndEnz0002015505 |
| Enzyme Type ID | protease015505 |
| Protein Name |
Zinc metalloproteinase nas-36 EC 3.4.24.- Nematode astacin 36 |
| Gene Name | nas-36 Bm1_07340 Bm2394 |
| Organism | Brugia malayi (Filarial nematode worm) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Spirurina Spiruromorpha Filarioidea Onchocercidae Brugia Brugia malayi (Filarial nematode worm) |
| Enzyme Sequence | MKEIAHSQAYGNRVFSRDSAVDSKKDVSISAEQPKTISKLTPYLFEGDIFLSTKQAMNILDSLASKNKTNKKGQQRMAHDAPLYLFRGANEKGKRFAAEYDAKWFQFPIKYRFDESLDILHISQILKALEIWQSNTCIKFENDQEASGDYIEFFEGDGCYSMVGRFGGRQGISIGKGCERTGTIIHEVGHTLGLWHEQSRPDAEEYITVVKEYIIPSYISEFLTRSEHEITTFNVPYDLGSVMHYGSTAFSIDQRSKTLLTKDPFYQMTIGQRDSLSFYNIKLINEAYCKGDCKEKNECKNGGYLNPSNCQSCLCPSGFGGSKCEMHASSESNSKCGGTLKAIIDWQYIESPGYPDGYPTNVICNWLIETDKEERIEISFEDNFGIFCSSTCVDYIELKIGNDLANTGYRICCYDKPNDSLVSAKYQAVIIFRATTGEDTGFKLKFRKTMKPAQTTPSLPKTTTTAPHTTIVGNDIWSEWGEWSQCSRSCGACGIKSRLRICKTAQCSGKVQQFLTCNLQACPVDIRCTKVKFKNRLCADGNTCGKPGELLSSCSRPSCCPPFENVDGKCQTDQPLLIPLE |
| Enzyme Length | 581 |
| Uniprot Accession Number | D5FM38 |
| Absorption | |
| Active Site | ACT_SITE 187; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by 1,10-phenanthroline. {ECO:0000269|PubMed:20800010}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease. Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. {ECO:0000269|PubMed:20800010}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (8); Domain (4); Glycosylation (2); Metal binding (3); Propeptide (1) |
| Keywords | Cleavage on pair of basic residues;Disulfide bond;EGF-like domain;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 65,102 |
| Kinetics | |
| Metal Binding | METAL 186; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 190; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211; METAL 196; /note=Zinc; via tele nitrogen; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01211 |
| Rhea ID | |
| Cross Reference Brenda |