| IED ID | IndEnz0002015523 |
| Enzyme Type ID | protease015523 |
| Protein Name |
Myosin-binding protein C, slow-type Slow MyBP-C C-protein, skeletal muscle slow isoform |
| Gene Name | MYBPC1 MYBPCS |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDWTLVETPPGEEQAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLPAEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIAQ |
| Enzyme Length | 1141 |
| Uniprot Accession Number | Q00872 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31264822, PubMed:31025394). In vitro, binds to native thin filaments and modifies the activity of actin-activated myosin ATPase. May modulate muscle contraction or may play a more structural role. {ECO:0000269|PubMed:31025394, ECO:0000269|PubMed:31264822}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (9); Beta strand (45); Chain (1); Compositional bias (1); Domain (10); Helix (3); Modified residue (4); Natural variant (8); Region (1); Sequence conflict (29); Turn (3) |
| Keywords | 3D-structure;Actin-binding;Alternative splicing;Cell adhesion;Disease variant;Immunoglobulin domain;Muscle protein;Phosphoprotein;Reference proteome;Repeat;Thick filament |
| Interact With | O75923; Q14324 |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 406; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q63518; MOD_RES 611; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q63518; MOD_RES 798; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q63518; MOD_RES 823; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:Q63518 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (6); X-ray crystallography (1) |
| Cross Reference PDB | 1X44; 2DAV; 2YUV; 2YUW; 2YUX; 2YUZ; 2YXM; |
| Mapped Pubmed ID | 10747208; 12628722; 16003462; 16918501; 19913121; 20379614; 20628086; 21061152; 21426302; 23414517; 24093860; 25679999; 26831109; |
| Motif | |
| Gene Encoded By | |
| Mass | 128,294 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |