| IED ID | IndEnz0002015531 |
| Enzyme Type ID | protease015531 |
| Protein Name |
Histone H2A deubiquitinase MYSM1 2A-DUB EC 3.4.19.- Myb-like, SWIRM and MPN domain-containing protein 1 |
| Gene Name | mysm1 si:ch211-59d15.8 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MADELDVVDIEGDECDEIVGDLSSAEILQDQYLQSAWRTNSSVLPWTLDSSISDENRQVIESMLLEEQYYFASKKAPKVAWTNEKTKVKKPLVKSSAAQTRWAEEEKELFEKGLAQFGRRWTKIAKLIGTRTVLQVKSYAKQYFKNKPKAEPAAEVTSANVTSVSSIQPHVSALTNAVRIERLSDDEDVDITDDFSDSELQSKKQPERSVSPDCNHHGELRPSLSDALLHLPSESTAADGQADPDFSEDTEIHHSEIDSEAVEESGNPFINLDSPSKHSLTGEEETELADKCESAECLEEEVEDQEEDEEEELRAPEQEVELDLNTITEEEKQAISEFFEGRPSKTPERYLKIRNYILDQWRRSKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFNCDQAIYNRPRLVDRSRLKESKDSLEAYHLAQRLQSMRTRKRRIRDVWGNWCDAKDLEGQTYEHLSAEELAIRREEMKKKGPRPSKLPKQRGSFDPFQLIPCKTFGEERQEPYSVIVCAEALIVMDIHAHVSMGEVIGLLGGTYEEEDKVLKICSAEPCNSLSTGLQCEMDPVSQTQASEVLGVKGLSVVGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAPFIGMIVSPYNPSNSSPQSQSTCLLVQEEPGPSGSHKFPYQFNMQCSAEPPDWSEVMRRAEWVVFKYRLCHGSVPMDRLFRRDSSLTCLEKMLLSIRTVLERLSEVDIETFLVQLESLFNTHFLSETGSSSTHLYETATQPQLLSFLSSEPISSSATEETSDGHDEPNTTGPDKLEQSCVEEEHDETVMQSTSAETV |
| Enzyme Length | 822 |
| Uniprot Accession Number | Q5RGA4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Domain (3); Erroneous gene model prediction (1); Erroneous initiation (1); Metal binding (3); Motif (1); Region (3); Sequence caution (1); Sequence conflict (7) |
| Keywords | Activator;Chromatin regulator;DNA-binding;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Reference proteome;Transcription;Transcription regulation;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20040115; 28450118; |
| Motif | MOTIF 596..609; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 92,803 |
| Kinetics | |
| Metal Binding | METAL 596; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 598; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 609; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |