| IED ID | IndEnz0002015582 |
| Enzyme Type ID | protease015582 |
| Protein Name |
External core antigen HBeAg Precore protein p25 |
| Gene Name | C |
| Organism | Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A) |
| Taxonomic Lineage | Viruses Riboviria Pararnavirae Artverviricota Revtraviricetes Blubervirales Hepadnaviridae Orthohepadnavirus (mammalian hepatitis B-type viruses) Hepatitis B virus (HBV) Hepatitis B virus subtype adw (HBV) Hepatitis B virus subtype adw2 Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A) |
| Enzyme Sequence | MQLFHLCLIISCTCPTVQASKLCLGWLWGMDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVGNNLEDPASRDLVVNYVNTNVGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSPSPRRRRSQSRESQC |
| Enzyme Length | 214 |
| Uniprot Accession Number | P0C625 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells. This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections. {ECO:0000255|HAMAP-Rule:MF_04076}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (2); Natural variant (3); Propeptide (1); Region (3); Repeat (3); Signal peptide (1); Site (1) |
| Keywords | Alternative initiation;Disulfide bond;Host nucleus;Host-virus interaction;Repeat;Secreted;Signal;Viral immunoevasion |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076, ECO:0000269|PubMed:2585603}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04076, ECO:0000269|PubMed:2585603}. |
| Modified Residue | |
| Post Translational Modification | PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.; PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255|HAMAP-Rule:MF_04076 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 24,580 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |