Detail Information for IndEnz0002015621
IED ID IndEnz0002015621
Enzyme Type ID protease015621
Protein Name Leucine aminopeptidase 1
EC 3.4.11.-
Leucyl aminopeptidase 1
LAP1
Gene Name LAP1 PABG_07703
Organism Paracoccidioides brasiliensis (strain Pb03)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Onygenales incertae sedis Paracoccidioides Paracoccidioides brasiliensis Paracoccidioides brasiliensis (strain Pb03)
Enzyme Sequence MKLPALLILGVAASTMVLAAIAPDQVPLNDAKKDELPEKFLIELAPGDTRWVTEDEKWELKREGLKFFDITAEVEQGFLPKVFPTPAVVNFPSELNRTAEVKQLASQLSKENMFNHLTNFTSFHTRYYKSTAGTQSATWLFEQVQQTVNNSLAVKYGAKVETFNHSWSQFSIIASIPGRTNKTVVVGAHQDSINMYLPTIQAPGADDDGSGTVTILEALRVLLQSDAVAQGNATNTIEFHWYSAEEAGLLGSQAVFSKYKNENRDIKSMLQQDMTGYSQGTLDAGEQESVGVITDYVHSGLTEFIMKVITGYCDIPFVLTKCGYACSDHASASRYGYPSAFVIESKFEHSSQRIHTMWDTVEYLDFDHMLQHAKMTLGLVYELAFAEL
Enzyme Length 388
Uniprot Accession Number C0SJ49
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.11.-
Enzyme Function FUNCTION: Extracellular aminopeptidase that allows assimilation of proteinaceous substrates. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (1); Glycosylation (6); Metal binding (6); Propeptide (1); Signal peptide (1)
Keywords Aminopeptidase;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Secreted;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 43,144
Kinetics
Metal Binding METAL 189; /note=Zinc 1; /evidence=ECO:0000250; METAL 207; /note=Zinc 1; /evidence=ECO:0000250; METAL 207; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 246; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 273; /note=Zinc 1; /evidence=ECO:0000250; METAL 355; /note=Zinc 2; catalytic; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda