| IED ID | IndEnz0002015660 |
| Enzyme Type ID | protease015660 |
| Protein Name |
Sodium/bile acid cotransporter 4 Na + /bile acid cotransporter 4 Solute carrier family 10 member 4 |
| Gene Name | SLC10A4 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MDGNDNVTLLFAPLLRDNYTLAPNASSLGPGTDLALAPASSAGPGPGLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAASHGPSPFPRPWAPHALPFWDTPLNHGLNVFVGAALCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSWAWINTPIVQLLPLGTVTLTLCSTLIPIGLGVFIRYKYSRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGSEMLHKRDPLDEDEDTDISYKKLKEEEMADTSYGTVKAENIIMMETAQTSL |
| Enzyme Length | 437 |
| Uniprot Accession Number | Q96EP9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Transporter for bile acids. {ECO:0000269|PubMed:23589386}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (5); Region (1); Site (1); Topological domain (8); Transmembrane (7) |
| Keywords | Cell membrane;Glycoprotein;Ion transport;Membrane;Reference proteome;Sodium;Sodium transport;Symport;Transmembrane;Transmembrane helix;Transport |
| Interact With | P29400-2; Q96LL9; Q96G79; Q8N511; A2RU14 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23589386}; Multi-pass membrane protein {ECO:0000269|PubMed:23589386}. |
| Modified Residue | |
| Post Translational Modification | PTM: Activated following N-terminal proteolytic cleavage by thrombin and/or proteases. {ECO:0000269|PubMed:23589386}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17106928; 23948907; 26084360; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,504 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |