| IED ID | IndEnz0002015685 |
| Enzyme Type ID | protease015685 |
| Protein Name |
Cysteine proteinase 2 EC 3.4.22.- Prestalk cathepsin |
| Gene Name | cprB CP2 DDB_G0279799 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MRLLVFLILLIFVNFSFANVRPNGRRFSESQYRTAFTEWTLKFNRQYSSSEFSNRYSIFKSNMDYVDNWNSKGDSQTVLGLNNFADITNEEYRKTYLGTRVNAHSYNGYDGREVLNVEDLQTNPKSIDWRTKNAVTPIKDQGQCGSCWSFSTTGSTEGAHALKTKKLVSLSEQNLVDCSGPEENFGCDGGLMNNAFDYIIKNKGIDTESSYPYTAETGSTCLFNKSDIGATIKGYVNITAGSEISLENGAQHGPVSVAIDASHNSFQLYTSGIYYEPKCSPTELDHGVLVVGYGVQGKDDEGPVLNRKQTIVIHKNEDNKVESSDDSSDSVRPKANNYWIVKNSWGTSWGIKGYILMSKDRKNNCGIASVSSYPLA |
| Enzyme Length | 376 |
| Uniprot Accession Number | P04989 |
| Absorption | |
| Active Site | ACT_SITE 147; /evidence=ECO:0000250; ACT_SITE 286; /evidence=ECO:0000250; ACT_SITE 343; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine proteinases 1 and 2 are believed to participate in the breakdown of protein during differentiation of Dictyostelium as a response to starvation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11553701; 12796308; 1321061; 1330484; 15470642; 17031003; 17878305; 18559084; 2159939; 2545528; 2555234; 2843819; 2897942; 7639520; 7926779; 8384208; 8612980; 8626023; 8657579; 9056234; 9601648; 9828114; |
| Motif | |
| Gene Encoded By | |
| Mass | 41,851 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |