| IED ID | IndEnz0002015694 |
| Enzyme Type ID | protease015694 |
| Protein Name |
Huntingtin Huntington disease protein HD protein Cleaved into: Huntingtin, myristoylated N-terminal fragment |
| Gene Name | HTT HD IT15 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGKQIKNLPEETFSRFLLQLVGILLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSDGCGGSFYTLDSLNLRARSMITTHPALVLLWCQILLLVNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCENLSTPTMLKKTLQCLEGIHLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPSPPVSSHPLDGDGHVSLETVSPDKDWYVHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLAPCLSLGMSEISGGQKSALFEAAREVTLARVSGTVQQLPAVHHVFQPELPAEPAAYWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPGLWSVVSSTEFVTHACSLIYCVHFILEAVAVQPGEQLLSPERRTNTPKAISEEEEEVDPNTQNPKYITAACEMVAEMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPVPSLSPATTGALISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEEEEEADAPAPSSPPTSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEVVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRVGALHGVLYVLECDLLDDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLIENYPLDVGPEFSASIIQMCGVMLSGSEESTPSIIYHCALRGLERLLLSEQLSRLDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKVSPGRTSDPNPAAPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYPQFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEELDRRAFQSVLEVVAAPGSPYHRLLTCLRNVHKVTTC |
| Enzyme Length | 3142 |
| Uniprot Accession Number | P42858 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.; FUNCTION: [Huntingtin, myristoylated N-terminal fragment]: Promotes the formation of autophagic vesicles. {ECO:0000269|PubMed:24459296}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (1); Chain (2); Compositional bias (5); Helix (2); Lipidation (1); Modified residue (15); Motif (1); Mutagenesis (10); Natural variant (15); Region (8); Repeat (5); Sequence conflict (1); Site (5); Turn (1) |
| Keywords | 3D-structure;Acetylation;Apoptosis;Cytoplasm;Cytoplasmic vesicle;Disease variant;Endosome;Lipoprotein;Mental retardation;Myristate;Neurodegeneration;Nucleus;Phosphoprotein;Reference proteome;Repeat;Triplet repeat expansion;Ubl conjugation |
| Interact With | Q9H7C9; Q6PCB6; Q9ULW3; P60709; P63261; P42025; Q15848; Q9Y4W6; Q53H12; Q53H12-2; Q5TGY3; Q9UIJ7; P14550; P31749; Q3SY69; P04075-2; Q9H553; Q8IWZ3-3; Q6ZTN6-2; Q5TZF3-1; Q16853; P63010-2; O00203; Q9Y2T2; P05067; P48444; Q9NP61; P53365; Q8N264; Q52LW3-2; Q0P5N6; Q6P1M9; Q86TN1; Q9Y575-3; Q6XD76; Q96FT7-4; Q12797-6; Q12797-7; Q96DT6; Q8WXF7; P25705; P24539; P48047; Q15904; P61421; P21281; Q9UI12; Q9UQB8-3; Q9UQB8-6; Q16520; Q9NRL2; Q9BUW7; Q8WY36-3; P51572; Q14457; Q00994; O15392; Q9GZL8; P38398-6; Q8WUW1; Q9H6J7-2; Q32Q52; Q13901; Q6P1W5; Q9BXJ4; Q9NUB4; Q6P5X5-2; Q8N865; Q9BRJ6; Q8IVU9; P0DP24; Q14012; Q8N5S9-2; Q9HC96; P29466-3; P42574; P55212; P55210; P22681; P0DN79; Q5JTY5; P83916; Q96HB5; Q96M83-3; Q9Y3X0; Q13939; Q9NPC3; P24863; O96020; P51959; P78371; P48643; P40227; P50990; P13987; Q9H3Q1; Q99459; O00311; Q9BWT1; P55290; O95674; Q8N2Z9; Q7Z7K6; Q9P2H0; Q53EZ4; Q96MT8-3; Q8NHQ1-3; P41208; Q9Y6H1; Q9NX63; Q12873; Q9HD42; O43633; Q9H444; Q9UHD4; P06732; Q9Y240; Q92478; Q16740; Q8NCR9; Q9H9A5; Q9H9A5-3; Q9UIV1; P09543; Q96MW5; P53618; Q9UNS2; Q86WV2; P10606; P12074; P09669; Q9UKF6; A2RRE8; Q9BSW2; P16220; Q92793; Q6UXH1-2; P46108; Q14194; A0A140G945; P53672; P04141; P48730-2; P50461; P56545-3; P35222; Q13618; Q93034; Q8TB03; P08574; P20815; Q5D0E6-2; Q9UN19; Q9UER7; Q15038; Q9UJU6; P61962; Q9H816; Q13561; Q9UJW0; Q9UHI6; Q9NR30; O00148; Q9UJV9; Q14154; P78524; P17661; Q05D60; Q5T7M9-2; P09622; P36957; O60479; P31689; Q96EY1; Q9UDY4; O75190-2; Q9NVH1; Q5F1R6; Q9NNZ3; O14645; Q05193; P50570-2; Q9H147; Q9H3H5; Q16555; Q9BPU6; Q14204; P63167; A0AVK6; Q13011; O60869; Q3B7T1; Q05639; P24534; P29692; P13639; Q12805; O14602; P20042; P41091; O75821; Q13347; Q14240-2; O60573; P55010; O95163; Q9Y6C2-2; Q8TC29; P06733; Q9Y5L3; O75356; A0A0C4DH22; Q8TE68-3; Q2NKX8; A1L162; Q96DN0; Q6NXG1-3; Q9UI08-2; Q01844-4; O00471; Q99504; P15311; P23610; Q6SJ93; Q96GL9; Q96KS9; Q5HYJ3-3; Q5JUQ0; Q8IZU1; Q9NPI8; Q8TC84; Q9NSD9; P49327; Q53R41; Q8NFZ0; P09467; Q99689; Q9UHY8; Q13643; Q9BVA6; P26885; O75955; Q8N3X1; Q3SYB3; Q6PIV2; O95073-2; P02792; P06241-3; Q9ULV1; Q7L622; Q13283; Q9UQC2; Q8N4A0; P04406; P28676; P14136; Q9NXC2; Q9UG22; Q9Y2X7; P48060; P09471; P62873; P62879; Q08379; Q9H4A5; Q8IYG2; P51674; Q86YB0; Q7Z602; Q96D09; Q96SL4; Q13588; Q8IY40; P49840; Q9Y5Q9; Q9BZE4; O75409; Q93079; Q6NXT2; P68431; Q71DI3; P62805; P40939; P54257-2; Q99871; O00165; Q8N779; Q969S8; Q9UBN7; Q9HCC6; Q9UBP5; O00291; Q9BW71; P52790; P08397; Q9NP66; Q9P0W2; P09429; P07910; P07910-2; P61978; P20719; O43248; P09017; P00492; P0DMV8; P54652; P11142; Itself; Q12891; Q9NX55; Q02363; Q8IY31-2; Q8IY31-3; Q9NWB7; P22692; Q14005-2; Q16891; P29218-3; Q9UNL4; Q8WYH8-2; Q8NBZ0; Q8TEX9; O00410-3; Q6DN90-2; Q96N16; Q92993; Q13303; Q9Y691; Q96SI1-2; Q8N5Z5; A0A384DVV8; Q6ZU52; Q5T5P2-6; O14901; Q9Y4X4; P57682; Q53G59; Q9Y2M5; O60259; O15229-2; Q9Y448; O00505; P05783; P08727; P35900; Q14525; P60409; Q8IUC1; Q8IUC2; Q9BYQ4; Q96JM7-2; O43813; Q92615; O95447; Q5T7P3; Q86U70-2; Q9BYZ2; P07195; O95751; Q8TCE9; Q9H2C1; Q9UPM6; Q68G74; Q9H9Z2; Q8N0U6; Q9H0V9; Q8TBB1; Q8N448; A2RU56; Q1L5Z9; Q14693; Q96CN5; Q32MZ4; O95777; Q9Y383; Q8N1E2; Q9H063; P43357; Q96M61; Q8N7X4; Q96EH3; Q99683; Q00266; P43243; P56270-2; Q9UIS9; O95243-2; Q96EZ8; Q9HAF1; P51608; Q96RN5; Q96RN5-2; Q15528-2; Q9H204; Q96HR3; Q9Y3C7; P50221; Q8N6F8; Q8TDB4; O94851; A4FUJ8; Q9BUB5; Q9H000; P22033; P51948; P41218; Q16653-13; Q15014; Q8N594; P49959; Q9Y605; Q96HT8; Q9BYD1; O43196-4; Q9Y3D2; P35548; P02795; O43312; Q9ULD2-3; Q9ULD2-4; O15069; Q9ULW6; P54920; Q14596; P14598; Q969V3; O75376; Q99608; Q9P0J0; Q16795; O96000; O96000-2; Q9Y6M9; P28331-5; O43920; O76041; I6L9F6; Q86SG6; Q13562; P19838-2; Q8N5V2; Q9NX24; Q9UBE8; Q96AM0; O00746; P56597; Q9C002; Q9Y239; O15130-2; Q9Y639-1; Q13133-2; Q86WQ0; Q6X4W1-6; P36639-4; Q9NZJ9; Q7Z417; Q9BVL2; Q9NPJ8-3; Q96GC1; Q02218; Q86WS3; Q6B0I4; Q96CV9; Q96CV9-2; Q92882; Q3ZCN5; Q8IVL6-2; P13674; Q6VY07; Q9BY11; Q13177; Q9P286; Q9NP74; Q8N3R9; Q86WK9; Q99497; Q9HBE1-4; Q9BYU1; Q9Y5G3-2; Q6UW60-2; P54750-4; Q15119; Q96HC4; O15530-4; Q13113; Q96FA3; Q9BRX2; O00541; Q99471; P35080; O75925; Q8N2W9; Q8WXW3; Q9NRD5; Q8WWB5; P42336; P27986; P27986-2; O00459; Q92569; Q9BXM7; Q96J94; P14618; Q9BS22; Q9UP65; Q15149; Q9HCM2-3; Q6P1K2-3; Q8NBT0; Q9H2U2-3; Q9H2U2-6; Q07869; Q03181-2; P37231; Q59EV6; O43447; O60437; P62136; Q96T49; Q6ZMI0-5; Q16537; O75170-4; O60828; P49642; P17612; P55345; P04156; Q53TL4; Q8WWY3; O75400; O75400-2; Q96M27; A0A0C4DFM3; P25786; P25789; P60900; O14818; P20618; P49721; P49720; P28072; P28062-2; P17980; O00487; O43242; P55036; P51665; Q13635-3; P41222; Q13882; Q9UHX1-2; Q9UHX1-6; P47897; Q15286; P61020; P54725; P78406; P62826; P46060; Q8WZA2; Q13702-2; P20936; Q6T310; Q9NS23-4; P50749; Q8WWW0-2; O43251-3; P57052; P52756; Q93062-3; Q9UKA8; Q15293; Q9GZR2; Q8IXN7; Q6NUQ1; Q5TAB7; Q6ZNA4-2; Q9ULX5; Q96D59; Q5VTR2; Q9H0F5-2; O75150; P26373; Q6NZ55; P61313; Q07020; P84098; P35268; Q9UNX3; P61353; P62899; P36578; P25398; P62244; P39019; P62979; P23396; P46782; Q16799-3; Q6ZNE9; Q66K80; Q96GQ5; P48443; Q8N488; P25815; Q8N6K7-2; G3V2R1; O75446; Q6UVJ0; Q9BY12-3; Q8WVM8; Q96NL6-3; Q12765-2; O00560; P55735-3; Q15437; Q96T21; O43236; Q14141; Q16181-2; Q9UHV2; Q9BYW2; Q15047-2; Q12874; Q15393; A0A1P0AYU5; Q2NKQ1-4; Q99961; Q99963; Q9NR46; Q8IYI0; Q9Y2K2-7; Q96ST3; P43004; Q02978; Q00325-2; Q8NCS7; Q12824; Q8TAQ2-2; Q96GM5; Q16637-3; Q9HCE7-2; P60880-2; O95721; P37840; P62316; P62306; Q13573; Q9UMY4; O60749; Q8WV41; Q8WXH5; Q9BX66; O95416; Q9BT81; Q02447; Q3SY56; Q99932-2; Q9NY87; Q7Z6I5; Q8NHS9; Q8IUW3; P61009; Q01892; Q1W4C9; Q7Z698; Q13501; P36956; Q7Z6B7; O75044; O43295; Q8IXS7; Q9BXP5; Q9BXP5-3; Q9BXP5-4; P05455; Q9NP77; P50502; O75886; P49675; Q9H668; Q9Y3F4; A1L378; Q9UNE7; O14662-5; P61764; Q9BR01-2; Q8NBJ7; P63165; P55854; A1L190; Q92797; Q92797-2; P08247; Q9BQS2-2; Q8N9I0; Q9BQG1; Q5T7P8-2; O75410; O75410-7; Q86TJ2-3; P37802; P37837; Q6NW12; Q92844; Q92844-3; Q9H2K8; Q5VWN6; Q92609; Q32MN6; Q16650; Q9Y458; O14776; P17987; Q8TDR4; P28347-2; Q86WV5; Q96A09; Q15554-4; Q96M34; Q03403; Q92734; O95455; P37173; P21980-2; Q96MW7; O60220; Q08117; Q9BZW5-2; Q96EY4; Q9NUM4; Q12893; Q6UW68; Q8WW34-2; Q9NV96-2; Q9BTV4; Q9BQJ4; Q8IUR5-4; Q71RG4-4; Q13829; O00300; O95150; Q96KP6; P22105-1; Q9NS69; P04637; P60174; Q12933; O14545; P19474; Q9UPQ4-2; P0CI25; Q15642-2; Q15654; Q99614; Q6DKK2; Q5W5X9-3; Q71U36; P07437; Q9BUF5; Q9UGJ1-2; Q15672; Q8WVJ9; Q99757; Q6PKC3; Q01081; P22314; Q9BSL1; P0CG48; Q9Y2X8; P62256; P63279; P61086; Q9UHD9; Q92890; O75385; Q495M9; Q9UMW8; O75604-3; Q9UPU5; Q8NFA0-2; Q93008; Q9BVJ6; Q9NYH9; Q08AM6; Q9HCJ6; P55072; P45880; P40337-2; P09327-2; P08670; Q9UK41; Q8NEZ2; O75351; Q9BTA9; Q9BTA9-5; O75554; Q8IZQ1; Q9GZS3; A4D1P6; Q15007-2; O00308; Q9HCS7; Q8WTP9; P12956; O95070; P31946; Q9H869-2; Q9H171; Q05516; O43167-2; Q53FD0-2; Q6PEW1; Q8IUH5; Q8WVZ1-3; G3V1X1; Q6ZN57; Q96K21; Q9UKY1; Q96EF9; Q9BRR0; Q15776; Q96NC0; O95789-4; P52744; Q9UJW8-4; P17023; Q9BSG1; Q9Y2X9; Q9HBT8; Q9NR11-2; Q8N895; Q9C0F3; Q8N0Y2-2; Q6ZNH5; O60304; Q8N988-2; Q68EA5; Q7Z3I7; Q96N77-2; Q8N720; Q5TEC3; Q3KNS6-3; O15535; Q2QGD7; A8K3Q9; A8K878; B7Z3E8; Q0VG73; Q7L8T7; Q86V28; Q96IQ6; O88485; P54256; P51660; P29994; Q99KR7 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Huntingtin]: Cytoplasm {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16476778, ECO:0000269|PubMed:7647777}. Nucleus {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16391387}. Early endosome {ECO:0000269|PubMed:16476778}. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778). {ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:16476778}.; SUBCELLULAR LOCATION: [Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24459296}. |
| Modified Residue | MOD_RES 9; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:21685499"; MOD_RES 176; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:21685499"; MOD_RES 234; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:21685499"; MOD_RES 343; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:21685499"; MOD_RES 411; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18669648"; MOD_RES 417; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:P42859"; MOD_RES 419; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:P42859"; MOD_RES 432; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569"; MOD_RES 442; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:21685499"; MOD_RES 640; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 643; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:23186163"; MOD_RES 1179; /note="Phosphoserine; by CDK5"; /evidence="ECO:0000269|PubMed:17611284"; MOD_RES 1199; /note="Phosphoserine; by CDK5"; /evidence="ECO:0000269|PubMed:17611284, ECO:0007744|PubMed:23186163"; MOD_RES 1870; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231"; MOD_RES 1874; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163" |
| Post Translational Modification | PTM: [Huntingtin]: Cleaved by caspases downstream of the polyglutamine stretch (PubMed:8696339, PubMed:9535906, PubMed:10770929, PubMed:29802276). The resulting N-terminal fragments are cytotoxic and provokes apoptosis (PubMed:10770929). {ECO:0000269|PubMed:10770929, ECO:0000269|PubMed:29802276, ECO:0000269|PubMed:8696339, ECO:0000269|PubMed:9535906}.; PTM: [Huntingtin]: Forms with expanded polyglutamine expansion are specifically ubiquitinated by SYVN1, which promotes their proteasomal degradation. {ECO:0000269|PubMed:17141218}.; PTM: [Huntingtin]: Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. {ECO:0000269|PubMed:17611284}.; PTM: [Huntingtin, myristoylated N-terminal fragment]: Myristoylated at Gly-551, following proteolytic cleavage at Asp-550. {ECO:0000269|PubMed:24459296, ECO:0000269|PubMed:29802276}. |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (3); Electron microscopy (6); X-ray crystallography (13) |
| Cross Reference PDB | 2LD0; 2LD2; 3IO4; 3IO6; 3IOR; 3IOT; 3IOU; 3IOV; 3IOW; 3LRH; 4FE8; 4FEB; 4FEC; 4FED; 4RAV; 6EZ8; 6N8C; 6RMH; 6X9O; 6YEJ; 7DXJ; 7DXK; |
| Mapped Pubmed ID | 10823891; 11008591; 11105061; 11121205; 11137014; 11149616; 11379408; 11432963; 11487199; 11595021; 11642542; 11738012; 11739372; 11745989; 11792860; 11807410; 11854752; 11870213; 11906693; 11939977; 11971872; 11973620; 11988536; 12062094; 12135980; 12191472; 12204002; 12393306; 12427879; 12466534; 12548366; 12555240; 12569151; 12657678; 12682342; 12784292; 12799135; 12807877; 12810713; 12824708; 12873381; 12952868; 12956863; 14527999; 14570710; 14570907; 14572927; 14617779; 14657499; 14714490; 14725621; 14743370; 14978262; 14985437; 15032971; 15140195; 15140196; 15163634; 15240759; 15261377; 15273431; 15312898; 15316797; 15340079; 15351733; 15359012; 15383276; 15468075; 15496672; 15603740; 15610167; 15689617; 15716522; 15717026; 15809304; 15843398; 15890517; 15911879; 15916486; 15951191; 15994095; 16006135; 16085648; 16115810; 16115812; 16162412; 16169070; 16183657; 16204350; 16278683; 16286508; 16324236; 16365166; 16417581; 16452635; 16452687; 16473015; 16522639; 16595690; 16606912; 16729030; 16777606; 16782707; 16835690; 16968735; 16973623; 17012230; 17098699; 17115386; 17124493; 17126554; 17135277; 17151278; 17161366; 17189290; 17201528; 17208201; 17240517; 17276991; 17299753; 17361007; 17403029; 17409200; 17433700; 17500595; 17519223; 17548833; 17610899; 17660463; 17687393; 17708681; 17902043; 17941857; 17947297; 17948889; 17952586; 17975550; 18006506; 18029446; 18063376; 18065495; 18068007; 18078716; 18091069; 18157708; 18192679; 18255062; 18267960; 18337408; 18380890; 18400894; 18445618; 18504298; 18558632; 18586675; 18615096; 18632688; 18640989; 18649400; 18651325; 18718937; 18772195; 18922795; 18981372; 18992820; 19018245; 19026253; 19027857; 19039036; 19059613; 19115052; 19130884; 19133136; 19196932; 19204007; 19240033; 19240112; 19249009; 19250382; 19266143; 19268537; 19270310; 19270701; 19289118; 19361448; 19386911; 19465745; 19488402; 19492089; 19498170; 19525941; 19566678; 19628478; 19661690; 19667213; 19710014; 19726651; 19752198; 19776381; 19915590; 19916101; 19933700; 19969308; 20016493; 20016831; 20018729; 20026071; 20026656; 20056037; 20064390; 20126661; 20140226; 20145253; 20154145; 20204693; 20232225; 20360314; 20379614; 20417604; 20444706; 20494921; 20531388; 20708032; 20710011; 20800603; 20858895; 20864123; 20864533; 20875859; 21044956; 21087194; 21147489; 21169558; 21177255; 21192926; 21245084; 21248742; 21257639; 21280221; 21310951; 21315254; 21320997; 21322024; 21336284; 21364626; 21454471; 21458571; 21465263; 21482444; 21501628; 21509658; 21515588; 21518730; 21519949; 21540131; 21875723; 21887328; 21889504; 21889981; 21896647; 21954231; 21971427; 21983719; 21984825; 21985783; 21997870; 22011578; 22048026; 22072510; 22100810; 22101303; 22103299; 22110140; 22119730; 22123826; 22162197; 22178474; 22179316; 22219281; 22234237; 22235343; 22306231; 22306738; 22337954; 22352297; 22359536; 22375012; 22399227; 22409360; 22422149; 22433867; 22445760; 22511757; 22556411; 22573320; 22580459; 22623107; 22642889; 22735540; 22801429; 22815947; 22835334; 22891683; 22917585; 22974559; 22984513; 23012356; 23051704; 23071649; 23115180; 23160193; 23190281; 23225006; 23275563; 23293686; 23297360; 23300147; 23303669; 23305455; 23315009; 23319588; 23339311; 23416715; 23443539; 23575829; 23583659; 23624566; 23768628; 23774650; 23871671; 23898200; 23908352; 23966247; 23980182; 24054538; 24081492; 24086178; 24105466; 24196953; 24199621; 24217578; 24277524; 24291262; 24314096; 24377263; 24405192; 24407293; 24412394; 24415136; 24459107; 24471773; 24505464; 24584051; 24705354; 24747660; 24784230; 24798518; 24819723; 24836077; 24998512; 25017010; 25041730; 25042851; 25062733; 25092318; 25131594; 25143394; 25205111; 25271967; 25351248; 25380050; 25380582; 25398943; 25416977; 25446099; 25452431; 25464275; 25540325; 25558820; 25686248; 25726852; 25736541; 25773959; 25849918; 25866151; 25938884; 25995452; 26001312; 26010866; 26020223; 26106822; 26111612; 26165689; 26218986; 26264729; 26293574; 26333261; 26369532; 26450664; 26496610; 26529236; 26540094; 26586297; 26652744; 26673834; 26808260; 26850319; 26863614; 26953320; 26959244; 26980106; 27002149; 27082842; 27206983; 27220690; 27335115; 27377031; 27382061; 27402890; 27466181; 27570076; 27678206; 27721240; 27721444; 27740685; 27840155; 27870408; 27988204; 28017939; 28096892; 28111121; 28153533; 28165127; 28282438; 28286179; 28368337; 28369732; 28384479; 28387881; 28436437; 28453524; 28465506; 28494017; 28499347; 28539049; 28550168; 28550267; 28570578; 28617590; 28621522; 28653853; 28674979; 28698602; 28753941; 28864412; 28869595; 28900094; 28920551; 28937758; 28971465; 29093475; 29151587; 29162692; 29171910; 29212816; 29225330; 29282287; 29324753; 29362455; 29378824; 29401586; 29460266; 29510748; 29526547; 29601786; 29619771; 29627459; 29630769; 29668904; 29685790; 29713895; 29727175; 29789657; 29891550; 29912367; 29932473; 29956026; 30069866; 30072438; 30103339; 30185623; 30209243; 30256717; 30315108; 30332437; 30358836; 30389496; 30423259; 30452683; 30583877; 30624705; 30802639; 30808748; 30994454; 31282030; 31296921; 31300691; 31346086; 31359503; 31361762; 31428776; 31444920; 31450785; 31466833; 31638189; 31677786; 31681295; 31757420; 31814404; 31828084; 31844074; 31928144; 32093570; 32407769; 32422281; 32439599; 32560122; 32592593; 32598938; 32652810; 32668197; 32696070; 32735619; 32757223; 32805086; 32820193; 32821928; 32878904; 32894247; 32913184; 33023443; 33057179; 33086646; 33130095; 33159825; 33219289; 33228555; 33242422; 33247537; 33256402; 33272184; 33310753; 33432339; 33468657; 33572172; 33576152; 33579864; 33644966; 33674575; 33692166; 33909994; 34201610; 34239038; 34445125; 34492254; 34520257; 34600937; 34772920; 34830381; 34880419; 7727632; 9285789; 9668110; 9798945; |
| Motif | MOTIF 2395..2404; /note=Nuclear export signal; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 347,603 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |