| IED ID | IndEnz0002015706 |
| Enzyme Type ID | protease015706 |
| Protein Name |
Beta-catenin-like protein hmp-2 Protein humpback-2 |
| Gene Name | hmp-2 K05C4.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPPTSAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPNFFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNEENLTQLIIKLLEIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTARHSLAEEAQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGARAVESTGVSALLMESRGSQYKSVVTYANGVLSNLKRGDSAAIMNMSNSYDYEMSGSAADWQRDGLERELFAEMYPTNDGGHSESINMALNNSQMRPNHNWYDTDL |
| Enzyme Length | 678 |
| Uniprot Accession Number | O44326 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (PubMed:26412237). {ECO:0000269|PubMed:26412237, ECO:0000269|PubMed:9531567}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (1); Chain (1); Helix (40); Mutagenesis (3); Repeat (5); Turn (2) |
| Keywords | 3D-structure;Cell adhesion;Cell junction;Developmental protein;Reference proteome;Repeat |
| Interact With | Q967F4 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:25850673, ECO:0000269|PubMed:9531567}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4) |
| Cross Reference PDB | 4R0Z; 4R10; 4R11; 5XA5; |
| Mapped Pubmed ID | 10531027; 11099033; 11483502; 11904378; 12023307; 12445391; 12819787; 12847081; 14704431; 15166316; 15791247; 15958510; 16845399; 17164286; 17486083; 17601533; 17704769; 17897480; 18718757; 19343510; 19551147; 20126385; 20515680; 20689042; 21034729; 21059849; 21085631; 21110867; 21177967; 21367940; 21575624; 22004469; 22347378; 22560298; 22901814; 23800452; 25487147; 25938815; 26063786; 26443865; 26780296; 26919528; 26923492; 27506200; 28298447; 28842483; |
| Motif | |
| Gene Encoded By | |
| Mass | 74,511 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |