IED Industry Enzyme Database

Detail Information for IndEnz0002015729
IED ID IndEnz0002015729
Enzyme Type ID protease015729
Protein Name Insulin
Cleaved into: Insulin B chain; Insulin A chain
Gene Name INS
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Enzyme Length 110
Uniprot Accession Number P01308
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (5); Disulfide bond (3); Erroneous gene model prediction (1); Helix (5); Natural variant (27); Peptide (2); Propeptide (1); Signal peptide (1); Turn (3)
Keywords 3D-structure;Alternative splicing;Carbohydrate metabolism;Cleavage on pair of basic residues;Diabetes mellitus;Direct protein sequencing;Disease variant;Disulfide bond;Glucose metabolism;Hormone;Pharmaceutical;Reference proteome;Secreted;Signal
Interact With Q6UY14-3; A8MQ03; P14735-1; Itself; P06213-2; Q07627; P0DPK4; P11142
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000269|PubMed:14426955
Structure 3D NMR spectroscopy (72); Electron microscopy (13); X-ray crystallography (211)
Cross Reference PDB 1A7F; 1AI0; 1AIY; 1B9E; 1BEN; 1EFE; 1EV3; 1EV6; 1EVR; 1FU2; 1FUB; 1G7A; 1G7B; 1GUJ; 1HIQ; 1HIS; 1HIT; 1HLS; 1HTV; 1HUI; 1IOG; 1IOH; 1J73; 1JCA; 1JCO; 1JK8; 1K3M; 1KMF; 1LKQ; 1LPH; 1MHI; 1MHJ; 1MSO; 1OS3; 1OS4; 1Q4V; 1QIY; 1QIZ; 1QJ0; 1RWE; 1SF1; 1SJT; 1SJU; 1T0C; 1T1K; 1T1P; 1T1Q; 1TRZ; 1TYL; 1TYM; 1UZ9; 1VKT; 1W8P; 1XDA; 1XGL; 1XW7; 1ZEG; 1ZEH; 1ZNJ; 2AIY; 2C8Q; 2C8R; 2CEU; 2G54; 2G56; 2H67; 2HH4; 2HHO; 2HIU; 2JMN; 2JUM; 2JUU; 2JUV; 2JV1; 2JZQ; 2K91; 2K9R; 2KJJ; 2KJU; 2KQP; 2KQQ; 2KXK; 2L1Y; 2L1Z; 2LGB; 2LWZ; 2M1D; 2M1E; 2M2M; 2M2N; 2M2O; 2M2P; 2MLI; 2MPG; 2MPI; 2MVC; 2MVD; 2N2V; 2N2W; 2N2X; 2OLY; 2OLZ; 2OM0; 2OM1; 2OMG; 2OMH; 2OMI; 2OMQ; 2QIU; 2R34; 2R35; 2R36; 2RN5; 2VJZ; 2VK0; 2W44; 2WBY; 2WC0; 2WRU; 2WRV; 2WRW; 2WRX; 2WS0; 2WS1; 2WS4; 2WS6; 2WS7; 3AIY; 3BXQ; 3E7Y; 3E7Z; 3EXX; 3FQ9; 3HYD; 3I3Z; 3I40; 3ILG; 3INC; 3IR0; 3JSD; 3KQ6; 3P2X; 3P33; 3Q6E; 3ROV; 3TT8; 3U4N; 3UTQ; 3UTS; 3UTT; 3V19; 3V1G; 3W11; 3W12; 3W13; 3W7Y; 3W7Z; 3W80; 3ZI3; 3ZQR; 3ZS2; 3ZU1; 4AIY; 4AJX; 4AJZ; 4AK0; 4AKJ; 4CXL; 4CXN; 4CY7; 4EFX; 4EWW; 4EWX; 4EWZ; 4EX0; 4EX1; 4EXX; 4EY1; 4EY9; 4EYD; 4EYN; 4EYP; 4F0N; 4F0O; 4F1A; 4F1B; 4F1C; 4F1D; 4F1F; 4F1G; 4F4T; 4F4V; 4F51; 4F8F; 4FG3; 4FKA; 4GBC; 4GBI; 4GBK; 4GBL; 4GBN; 4IUZ; 4IYD; 4IYF; 4NIB; 4OGA; 4P65; 4RXW; 4UNE; 4UNG; 4UNH; 4WDI; 4XC4; 4Y19; 4Y1A; 4Z76; 4Z77; 4Z78; 5AIY; 5BOQ; 5BPO; 5BQQ; 5BTS; 5C0D; 5CJO; 5CNY; 5CO2; 5CO6; 5CO9; 5E7W; 5EMS; 5EN9; 5ENA; 5HPR; 5HPU; 5HQI; 5HRQ; 5HYJ; 5MAM; 5MHD; 5MT3; 5MT9; 5MWQ; 5T7R; 5UDP; 5UOZ; 5UQA; 5URT; 5URU; 5USP; 5USS; 5USV; 5UU2; 5UU3; 5UU4; 5VIZ; 5WBT; 5WDM; 5WOB; 6B3Q; 6B70; 6BFC; 6CE7; 6CE9; 6CEB; 6CK2; 6GNQ; 6GV0; 6H3M; 6HN5; 6JK8; 6JR3; 6K59; 6NWV; 6O17; 6P4Z; 6S34; 6S4I; 6S4J; 6SOF; 6TC2; 6TYH; 6U46; 6VEP; 6VER; 6VES; 6VET; 6X4X; 6Z7W; 6Z7Y; 7BW7; 7BW8; 7BWA; 7JP3; 7NHU; 7S4Y;
Mapped Pubmed ID 10052452; 10102273; 10211611; 10217147; 10218944; 10358014; 10391242; 10411933; 10480595; 10480625; 10489447; 10508408; 10521251; 10583407; 10615960; 10679020; 10723989; 10761932; 10903204; 10913147; 11035033; 11063744; 11075717; 11089560; 11092919; 11092920; 11101842; 11123908; 11140838; 11172815; 11278339; 11285137; 11306556; 11309201; 11343787; 11347740; 11376336; 11398136; 11401442; 11461920; 11462236; 11467836; 11468392; 11502799; 11511079; 11524020; 11600536; 11606170; 11689559; 11703931; 11726511; 11737239; 11738155; 11739440; 11742127; 11748249; 11756331; 11779231; 11779849; 11800057; 11815450; 11815463; 11825903; 11865063; 11866509; 11873862; 118839; 11912547; 11937112; 11953210; 11978629; 12011435; 12029093; 12032154; 12047362; 12051853; 12079889; 12086926; 12101177; 12111440; 12133430; 12136131; 12182905; 12186542; 12189018; 12196530; 12354137; 12364457; 12368292; 12388752; 12392301; 12403834; 12404181; 12426319; 12441313; 12479880; 12493740; 12529491; 12553549; 12589110; 12590147; 12595704; 12610512; 12620428; 12624089; 12631734; 12637980; 12639765; 12654724; 12657786; 12684222; 1270801; 12721156; 1272390; 12750767; 12754525; 12803245; 12821730; 12876340; 12881524; 12887316; 12917329; 12930990; 12946932; 1325671; 1354160; 1429623; 14514350; 14551916; 14592410; 14596591; 14599721; 14615605; 14616883; 14617756; 14633852; 14647005; 14651526; 14654841; 14657411; 14659752; 14671163; 14671189; 14671204; 14676208; 14679083; 14693412; 14704853; 14707040; 14715866; 14742712; 14744022; 14749349; 14979729; 14986111; 14988398; 15028719; 15046555; 15047631; 15095040; 15096212; 15111508; 15126243; 15126574; 15147182; 15161800; 15163889; 15170498; 15220197; 15230641; 15237706; 15240646; 15276842; 15277396; 1528899; 15305767; 15316008; 15351621; 15367890; 1549601; 15529622; 15537656; 15538935; 15561961; 15572341; 15581831; 15583859; 15589123; 15591776; 15610006; 15610023; 15613433; 15632110; 15632182; 15678496; 15684637; 15690086; 15699505; 15705595; 15705917; 15728195; 15788565; 15794638; 15834700; 15878873; 15880482; 15889096; 15919610; 15922332; 15928253; 15929679; 15936461; 15949705; 15956217; 15956745; 15962837; 15983206; 16006430; 16025255; 16025839; 16081366; 16098208; 16099818; 16123374; 16158220; 16246524; 16246845; 16251897; 16276008; 16307231; 16344718; 16344925; 16362283; 16380501; 16390390; 16418171; 16443778; 16497805; 16510972; 16552513; 16595598; 16608900; 16614815; 16627943; 16629714; 16633337; 16691379; 16714477; 16720719; 16723730; 16728398; 16731532; 16731859; 16736556; 16741735; 16751187; 16762918; 16799400; 16800793; 16814735; 16835468; 16840535; 16866381; 16868061; 16885156; 16940185; 16949073; 16951936; 16984975; 16996478; 17011062; 17011566; 17051221; 17052889; 17053071; 17065334; 17103462; 17105729; 17116217; 17127405; 17130532; 17157312; 17192475; 17192483; 17242212; 17253781; 17274799; 17279313; 17284223; 17291451; 17299081; 17310371; 17311896; 17327422; 17327440; 17327454; 17337306; 17339105; 17341563; 17342078; 17344504; 17348446; 17416760; 17433504; 17437081; 17464100; 17468256; 17468747; 17471492; 17473382; 17479246; 17497031; 17502420; 17506723; 17513702; 17520407; 17553505; 17554260; 17586504; 17595255; 17616349; 17620332; 17632545; 17652220; 17667841; 17675047; 17698984; 17700581; 17726611; 17760859; 17805200; 17827149; 17828388; 17846745; 17884811; 17890489; 17900700; 17901401; 17914103; 17920639; 17923791; 17925406; 17927562; 17937736; 17957153; 17972051; 17993259; 18029081; 18039179; 18039812; 18040865; 18057381; 18070774; 18072146; 18077505; 18083784; 18085551; 18086915; 18090240; 18093308; 18157793; 18162464; 18182008; 18198306; 18198311; 18211635; 18216377; 18220656; 18279373; 18283245; 18283256; 18283260; 18284601; 18292987; 18294642; 18305020; 18307789; 18310307; 18332129; 1837051; 18375961; 18388898; 18396350; 18404969; 18406720; 18417529; 18441389; 18449172; 18451997; 18483566; 18484335; 18491415; 1849145; 18520331; 18582564; 18620562; 18660489; 18662362; 18692115; 18716398; 18719673; 18767151; 18801842; 18809720; 18834984; 18839133; 18840770; 18853485; 18940880; 18951876; 18977386; 18981553; 18983503; 18996102; 19000139; 19000992; 19015319; 19020323; 19025443; 19037607; 19051206; 19052261; 19064572; 19073905; 19073967; 19094425; 19109418; 19141582; 19146426; 19152242; 19164740; 19188424; 19188433; 19188609; 19190820; 19214176; 19247282; 19249902; 19280057; 19296914; 19321435; 19321436; 19321446; 19324891; 19336408; 19338578; 19367319; 19430480; 19434426; 19445897; 19463742; 19466592; 19491387; 19556358; 19576174; 19578600; 19578796; 1961250; 19631211; 19680231; 19683528; 19688775; 19709092; 19742322; 19758564; 19767753; 19769745; 19773552; 19778377; 19785038; 19833889; 19845278; 19864624; 19885595; 1988957; 19898946; 19913026; 19913121; 19935854; 19948072; 19950226; 20007936; 20033399; 20034470; 20054344; 20098959; 20106974; 20119675; 20133622; 20133841; 20138117; 20142200; 20181952; 20190549; 20203524; 20208155; 20232313; 2025410; 20332111; 20345871; 20357092; 20357430; 20361993; 20378605; 20391195; 20427317; 20455999; 20468064; 20535137; 20564319; 20566319; 20568733; 20587420; 20607677; 20628086; 20628762; 20637885; 20647273; 20655470; 20724178; 20734064; 20738396; 20739464; 20805278; 20807650; 20808760; 20849903; 20863361; 20938745; 21036154; 21054880; 21059249; 21073664; 21094141; 2118650; 21193298; 21193618; 21203453; 21203503; 21219331; 21251282; 21281583; 21302286; 21308844; 21336277; 21352425; 21361910; 21427225; 21437235; 21442164; 21448434; 21454690; 21454697; 21462967; 21473587; 21507316; 21544516; 21559376; 21566073; 21574953; 21592955; 21646299; 21660954; 21707690; 21711374; 21724851; 21813805; 21816162; 21823539; 21867683; 21880708; 21884975; 21887289; 21900206; 21906630; 21911493; 2195544; 22003494; 22005517; 22013193; 22033917; 22065208; 22065581; 22068552; 22082268; 22094269; 22095122; 22132167; 22132232; 22167125; 22167126; 22193626; 22229322; 22235272; 22242132; 22245737; 22253890; 22290178; 22297303; 22307032; 22315413; 22350952; 22357962; 22359667; 22363506; 22378730; 22379117; 22383948; 22393448; 22403629; 22461323; 22465905; 22468791; 22547909; 22567146; 22577092; 22684034; 22718751; 22739332; 22748134; 22751690; 22763970; 22918957; 22940118; 22949029; 22950808; 22957706; 22967498; 22967500; 22972030; 22982989; 22993210; 23018458; 23043361; 23050777; 23092880; 23106816; 23133528; 23223446; 23227203; 23256685; 23275337; 23281053; 23289766; 23302862; 23321478; 23343390; 23348915; 23357976; 23404086; 23405181; 23410103; 23416304; 23428413; 23443243; 23447530; 23460020; 23463541; 23484124; 23510797; 23531221; 23584706; 23600561; 23624892; 23648896; 23692694; 23697264; 23718986; 23721563; 23729554; 23796517; 23820621; 23839779; 23886629; 23911422; 23933688; 23944770; 23980258; 24002365; 24022479; 24030901; 24036112; 24075908; 24081736; 2409350; 24119662; 24132974; 24139410; 24142430; 24146977; 24167603; 24184209; 24239544; 24279684; 24283070; 24302564; 24389353; 24446161; 24465779; 24468049; 24478457; 24479346; 24492466; 24506168; 24507870; 24529663; 24552441; 24559166; 24559912; 24559913; 24559914; 24559925; 24587638; 24606127; 24614131; 24628669; 24672804; 24677210; 24683100; 24713842; 24724616; 24778449; 24785155; 24806965; 24810472; 24811232; 24812634; 24819248; 24819707; 24828025; 24829924; 24829925; 24841383; 24845759; 24854384; 24885899; 24895638; 24906975; 24910105; 24971665; 25003985; 25007043; 25008428; 25015099; 25036495; 25047698; 25068948; 25092300; 25108160; 25126860; 25133511; 25139051; 25157818; 25200289; 25200290; 25200291; 25200304; 25220536; 25233421; 25255697; 25286859; 25305014; 25345799; 25355081; 25375650; 25380325; 25388749; 25408296; 25436559; 25458830; 25516545; 25523979; 25527324; 25529453; 25573092; 25583030; 25616509; 25627686; 25627966; 25649462; 2565838; 25665061; 25696117; 25697093; 25707205; 25721872; 25765664; 25849393; 25852025; 25853706; 25875578; 25892189; 25923089; 25940861; 25957006; 25965336; 25981372; 25987030; 26003327; 26063811; 26068931; 26078977; 26085090; 26103160; 26136127; 26192187; 26216854; 26225416; 26281834; 26289721; 26297026; 26321373; 26354543; 26402673; 26404065; 26420624; 26437244; 26469762; 2648161; 26492921; 26505114; 26519138; 26584065; 26592151; 26657615; 26684862; 2669954; 26707939; 26792393; 26822090; 26824044; 26836020; 26849622; 26858360; 26866713; 26921119; 26930065; 26950281; 26968895; 26981544; 26994470; 27012460; 27019958; 27052801; 27127999; 27129279; 27133621; 27183386; 27183389; 27257781; 27280334; 27300270; 27388232; 27398945; 27401534; 27459526; 27463367; 27487489; 27548502; 27572655; 27643615; 27659712; 27665380; 27667266; 27745529; 27768686; 27798656; 27846285; 27875310; 27889612; 27905149; 27907006; 27919543; 279930; 28000708; 28024260; 28042651; 28111382; 28116849; 28137793; 28181734; 28213469; 2822027; 28242267; 28263308; 28267407; 28268248; 28286049; 28300542; 28318878; 28325894; 28341309; 28343707; 28348075; 28406435; 28450972; 28466587; 28565926; 28597946; 28598606; 28693499; 28750074; 28758130; 28805732; 28855269; 28869884; 28877460; 28880472; 28880475; 28880478; 28919328; 2900981; 29040868; 2905485; 29086855; 29114034; 29114035; 29117231; 29132475; 29154275; 29175121; 29203512; 29222417; 29229776; 29252126; 29273204; 29303782; 29320365; 29376874; 29411439; 29444458; 29512653; 29531349; 29537934; 29588286; 29596046; 29633446; 29793481; 29804482; 29809159; 29880646; 29950119; 29950394; 30025187; 30103773; 30215464; 3035556; 30356040; 30375294; 30400868; 30409165; 30412052; 30414308; 30451800; 30528738; 3053705; 30586628; 30595379; 3061785; 30718702; 30770752; 30796294; 3080684; 3094007; 31012517; 31099751; 31176671; 31211453; 31394085; 31398795; 3142462; 31436533; 31442418; 3147185; 31473874; 31605659; 31642314; 31661671; 3166375; 31727777; 31827251; 31958230; 31964806; 32052124; 32061050; 32110371; 32254061; 32270361; 32275863; 32405973; 32433667; 32483339; 32719315; 32736653; 32829168; 3283564; 32916194; 32970831; 32992893; 33135678; 33154160; 33277949; 33411018; 33462295; 33482580; 33542101; 34089870; 34285405; 34318969; 34374650; 34433824; 34526989; 34593315; 34648911; 34649926; 3535329; 3886460; 3896518; 3914802; 6128593; 6309587; 6363172; 7014485; 731699; 7556990; 7626024; 7641683; 7691276; 7749917; 7781591; 7901001; 7951555; 8001155; 8025104; 8090735; 8097946; 8128252; 8159701; 8163057; 8253837; 8276779; 8312271; 8448120; 8464497; 8490014; 8590022; 8636227; 8648633; 8682206; 8688419; 8702728; 8760075; 8844841; 8870004; 8876979; 8916141; 8951384; 8991093; 8997178; 9006323; 9019408; 9054935; 9062110; 9100625; 9112396; 9148904; 9150144; 9163426; 9166668; 9193402; 9207799; 9224716; 9244307; 9288971; 9313762; 9323141; 9380700; 9382863; 9405360; 9449362; 9490716; 9514738; 9584121; 9609109; 9609114; 9631292; 9636695; 9637677; 9667917; 9671725; 9708987; 9751720; 9754833; 9793760; 9813131; 9862427; 9914469; 9990005;
Motif
Gene Encoded By
Mass 11,981
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda