| IED ID | IndEnz0002015764 |
| Enzyme Type ID | protease015764 |
| Protein Name |
Archaeal Lon protease EC 3.4.21.- ATP-dependent protease La homolog |
| Gene Name | AF_0364 |
| Organism | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
| Taxonomic Lineage | cellular organisms Archaea Euryarchaeota Archaeoglobi Archaeoglobales Archaeoglobaceae Archaeoglobus Archaeoglobus fulgidus Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) |
| Enzyme Sequence | MNEEVREILGGLDFESTKDVAVPERLIDQVIGQDHAVEAIKKAAVQKRHVMLIGSPGTGKSMLAKAMAELLPKEELEDILVYPNPQDPNQPKIRLVPAGKGREIVEAYKEEAMKKAQARNFLIFTLVFLVIGYTVLTNPGNLIWGIIAAVLILMMSRYFIPREDRNVPKLLVDNSDKVTAPFEDATGAHAGALFGDVRHDPFQSGGLETPAHERVEAGAIHRAHKGVLYIDEINTLTIESQQKLLTALQDKKFPITGQSERSSGAMVRTEPVPCDFILVAAGNLDALMGMHPALRSRIEGYGYEVYMNDTMPDTPENRQKLVRFVAQEVVKDGKIPHFDKYAVAEIIKEARRRAGRRNHLTLRLRELGGLVRTAGDIAKSEGSDIVRLEHVLKAKKIAKTIEEQLADKYIERRKDYKLFITEGYEVGRVNGLAVIGESAGIVLPIIAEVTPSMSKSEGRVIATGRLQEIAREAVMNVSAIIKKYTGRDISNMDVHIQFVGTYEGVEGDSASISIATAVISAIEGIPVDQSVAMTGSLSVKGEVLPVGGVTQKIEAAIQAGLKKVIIPKDNIDDVLLDAEHEGKIEVIPVSRINEVLEHVLEDGKKKNRLMSKFKELELAAV |
| Enzyme Length | 621 |
| Uniprot Accession Number | O29883 |
| Absorption | |
| Active Site | ACT_SITE 509; /evidence=ECO:0000255|PROSITE-ProRule:PRU01122; ACT_SITE 552; /evidence=ECO:0000255|PROSITE-ProRule:PRU01122 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively (By similarity). {ECO:0000250, ECO:0000269|PubMed:16002085}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 54..61; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (2); Beta strand (9); Chain (1); Domain (1); Helix (7); Mutagenesis (3); Nucleotide binding (1); Topological domain (3); Transmembrane (2); Turn (2) |
| Keywords | 3D-structure;ATP-binding;Cell membrane;Hydrolase;Membrane;Nucleotide-binding;Protease;Reference proteome;Serine protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (7) |
| Cross Reference PDB | 1Z0B; 1Z0C; 1Z0E; 1Z0G; 1Z0T; 1Z0V; 1Z0W; |
| Mapped Pubmed ID | 15983420; |
| Motif | |
| Gene Encoded By | |
| Mass | 68,208 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.53; |