| IED ID | IndEnz0002015839 |
| Enzyme Type ID | protease015839 |
| Protein Name |
Na + /H + exchange regulatory cofactor NHE-RF4 NHERF-4 Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 Na/Pi cotransporter C-terminal-associated protein 2 NaPi-Cap2 PDZ domain-containing protein 2 PDZ domain-containing protein 3 Sodium-hydrogen exchanger regulatory factor 4 |
| Gene Name | Pdzd3 Nherf4 Pdzk2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEAAADLRDTALLTLKFKFNPRLGIDNPVLSLAEDQDQSDPWNLHRPRFCLLSKEEEKTFGFHLQQHLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNIVAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHVVKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNRKLWQSGDQVTLLVAGLEVEEQCHQLGMPLAAPLAEGWALPAKPRCLNIEKGPEGFGFLLREEKGLDGRLGQFLWDVDPGLPADKAGMKAGDRLVAVAGESVDGLGHEETVSRIRAQGSCVSLIVVDPEADRFFSMVRLSPLLFLENTEIAAPPLAETKDLPVEDTVEPSGLAGSCQCFLYPGPGGGYGFRLCCVASGPCLFISQVTPGGSTARAGLQVGDTVLEVNGYPVGGDSELDRLQQLTEAEPPLCLKLGARNPQGLEAWISLESGEDWTLASELL |
| Enzyme Length | 498 |
| Uniprot Accession Number | Q99MJ6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity). Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity). {ECO:0000250|UniProtKB:Q86UT5}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (4); Sequence conflict (1) |
| Keywords | Cytoplasm;Membrane;Reference proteome;Repeat |
| Interact With | |
| Induction | INDUCTION: Isoform 2: Expressed in a circadian manner in the intestine. {ECO:0000269|PubMed:26756164}. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:26756164}; Peripheral membrane protein {ECO:0000305|PubMed:26756164}. Cytoplasm {ECO:0000269|PubMed:26756164}. Note=In kidney, predominantly localized to the subapical compartment of proximal tubular cells (PubMed:11099500). In intestinal epithelial cells, localizes to the ileal brush border and in a juxtanuclear compartment (PubMed:19088451). Expressed in the membrane, with relatively low expression in the cytoplasm (PubMed:26756164). {ECO:0000269|PubMed:11099500, ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:26756164}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12140190; 17645868; 18799693; 21267068; 21677750; 22967998; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,525 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |