| IED ID | IndEnz0002015841 |
| Enzyme Type ID | protease015841 |
| Protein Name |
Neprilysin-2 EC 3.4.24.- |
| Gene Name | nep-2 T05A8.4 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MRPDEEDGTTKSPGSRWTRIWAIIALILLILFLLVLGAAIYFYINYKDSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETSAVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIMESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW |
| Enzyme Length | 736 |
| Uniprot Accession Number | O44857 |
| Absorption | |
| Active Site | ACT_SITE 572; /evidence=ECO:0000255|PROSITE-ProRule:PRU01233; ACT_SITE 637; /note=Proton donor; /evidence=ECO:0000255|PROSITE-ProRule:PRU01233 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity. {ECO:0000269|PubMed:20929849, ECO:0000303|PubMed:20929849}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Coiled coil (1); Disulfide bond (5); Domain (1); Metal binding (3); Mutagenesis (2); Topological domain (2); Transmembrane (1) |
| Keywords | Coiled coil;Disulfide bond;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 12097347; 21085631; 21177967; 21367940; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 26009280; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 85,422 |
| Kinetics | |
| Metal Binding | METAL 571; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01233; METAL 575; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01233; METAL 633; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01233 |
| Rhea ID | |
| Cross Reference Brenda |