| IED ID | IndEnz0002015877 |
| Enzyme Type ID | protease015877 |
| Protein Name |
Adhesion and penetration protein autotransporter EC 3.4.21.- Cleaved into: Adhesion and penetration protein; Adhesion and penetration protein translocator Helper peptide |
| Gene Name | hap HI_0248 |
| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus Haemophilus influenzae Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
| Enzyme Sequence | MKKTVFRLNFLTACVSLGIASQAWAGHTYFGIDYQYYRDFAENKGKFTVGAKNIEVYNKEGQLVGTSMTKAPMIDFSVVSRNGVAALVGDQYIVSVAHNGGYNDVDFGAEGRNPDQHRFTYQIVKRNNYQAWERKHPYDGDYHMPRLHKFVTEAEPVGMTTNMDGKVYADRENYPERVRIGSGRQYWRTDKDEETNVHSSYYVSGAYRYLTAGNTHTQSGNGNGTVNLSGNVVSPNHYGPLPTGGSKGDSGSPMFIYDAKKKQWLINAVLQTGHPFFGRGNGFQLIREEWFYNEVLAVDTPSVFQRYIPPINGHYSFVSNNDGTGKLTLTRPSKDGSKAKSEVGTVKLFNPSLNQTAKEHVKAAAGYNIYQPRMEYGKNIYLGDQGKGTLTIENNINQGAGGLYFEGNFVVKGKQNNITWQGAGVSIGQDATVEWKVHNPENDRLSKIGIGTLLVNGKGKNLGSLSAGNGKVILDQQADEAGQKQAFKEVGIVSGRATVQLNSTDQVDPNNIYFGFRGGRLDLNGHSLTFKRIQNTDEGAMIVNHNTTQVANITITGNESITAPSNKKNINKLDYSKEIAYNGWFGETDKNKHNGRLNLIYKPTTEDRTLLLSGGTNLKGDITQTKGKLFFSGRPTPHAYNHLDKRWSEMEGIPQGEIVWDYDWINRTFKAENFQIKGGSAVVSRNVSSIEGNWTVSNNANATFGVVPNQQNTICTRSDWTGLTTCKTVNLTDTKVINSIPITQINGSINLTNNATVNIHGLAKLNGNVTLIDHSQFTLSNNATQTGNIKLSNHANATVNNATLNGNVHLTDSAQFSLKNSHFWHQIQGDKDTTVTLENATWTMPSDTTLQNLTLNNSTVTLNSAYSASSNNAPRHRRSLETETTPTSAEHRFNTLTVNGKLSGQGTFQFTSSLFGYKSDKLKLSNDAEGDYTLSVRNTGKEPVTLEQLTLIESLDNKPLSDKLKFTLENDHVDAGALRYKLVKNKGEFRLHNPIKEQELLNDLVRAEQAEQTLEAKQVEQTAEKQKSKAKARSRRAVLSDTPSAQSLLNALEAKQVEQTTETQTSKPKTKKGRSKRALSAAFSDTPFDLSQLKVFEVKLEVINAQPQVKKEPQDQEEQGKQKELISRYSNSALSELSATVNSMFSVQDELDRLFVDQAQSALWTNIAQDKRRYDSDAFRAYQQKTNLRQIGVQKALDNGRIGAVFSHSRSDNTFDEQVKNHATLTMMSGFAQYQWGDLQFGVNVGAGISASKMAEEQSRKIHRKAINYGVNASYQFRLGQLGIQPYLGVNRYFIERENYQSEEVKVQTPSLAFNRYNAGIRVDYTFTPTNNISVKPYFFVNYVDVSNANVQTTVNSTMLQQSFGRYWQKEVGLKAEILHFQLSAFISKSQGSQLGKQQNVGVKLGYRW |
| Enzyme Length | 1409 |
| Uniprot Accession Number | P44596 |
| Absorption | |
| Active Site | ACT_SITE 250; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable protease; promotes adherence and invasion by directly binding to a host cell structure. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (3); Compositional bias (1); Domain (2); Erroneous termination (1); Region (2); Signal peptide (1) |
| Keywords | Cell adhesion;Cell outer membrane;Hydrolase;Membrane;Periplasm;Protease;Reference proteome;Secreted;Serine protease;Signal;Transmembrane;Transmembrane beta strand;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Adhesion and penetration protein autotransporter]: Periplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Adhesion and penetration protein]: Secreted {ECO:0000305}. Cell surface {ECO:0000305}.; SUBCELLULAR LOCATION: [Adhesion and penetration protein translocator]: Cell outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 156,815 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |