| IED ID | IndEnz0002016012 |
| Enzyme Type ID | protease016012 |
| Protein Name |
Granzyme C EC 3.4.21.- B10 Cytotoxic cell protease 2 CCP2 |
| Gene Name | Gzmc Ctla-5 Ctla5 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MPPVLILLTLLLPLRAGAEEIIGGNEISPHSRPYMAYYEFLKVGGKKMFCGGFLVRDKFVLTAAHCKGSSMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYNPDDRSNDIMLLKLVRNAKRTRAVRPLNLPRRNAHVKPGDECYVAGWGKVTPDGEFPKTLHEVKLTVQKDQVCESQFQSSYNRANEICVGDSKIKGASFEEDSGGPLVCKRAAAGIVSYGQTDGSAPQVFTRVLSFVSWIKKTMKHS |
| Enzyme Length | 248 |
| Uniprot Accession Number | P08882 |
| Absorption | |
| Active Site | ACT_SITE 65; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 109; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 204; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (14); Chain (1); Disulfide bond (3); Domain (1); Helix (3); Propeptide (1); Sequence conflict (2); Signal peptide (1); Turn (4) |
| Keywords | 3D-structure;Cytolysis;Direct protein sequencing;Disulfide bond;Hydrolase;Lysosome;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytolytic granule. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 3FZZ; 3G01; |
| Mapped Pubmed ID | 10737774; 12039912; 12601154; 14499263; 1544892; 16339537; 16807745; 19017970; 19228596; 19299505; 19414782; 19592578; 21677750; 2307468; 31241463; 3260382; 3485287; 8917549; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,311 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |