| IED ID | IndEnz0002016015 |
| Enzyme Type ID | protease016015 |
| Protein Name |
Herinase EC 3.4.-.- Fragment |
| Gene Name | |
| Organism | Hericium erinaceus (Lion's mane mushroom) (Hydnum erinaceus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetes incertae sedis Russulales Hericiaceae Hericium Hericium erinaceus (Lion's mane mushroom) (Hydnum erinaceus) |
| Enzyme Sequence | VPSSFRTTITDAQLRG |
| Enzyme Length | 16 |
| Uniprot Accession Number | C0HJF2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Metalloprotease which hydrolyzes the alpha and gamma chains of fibrinogen. No activity against fibrinogen beta chains. Active against the synthetic tissue plasminogen activator substrate H-D-Ile-Pro-Arg-PNA and the synthetic plasmin substrate H-D-Val-Leu-Lys-pNA. {ECO:0000269|PubMed:23564433}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature for activity is 30 degrees Celsius. Stable below 40 degrees Celsius. Above 45 degrees Celsius the activity is sharply reduced. {ECO:0000269|PubMed:23564433}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.0. Active at pH 4.0 to pH 9.0. Stable from pH 5.5 to pH 7.0. {ECO:0000269|PubMed:23564433}; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Non-terminal residue (1) |
| Keywords | Blood coagulation;Direct protein sequencing;Fibrinolysis;Hemostasis;Hydrolase;Metal-binding;Metalloprotease;Protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,749 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |