| IED ID | IndEnz0002016078 |
| Enzyme Type ID | protease016078 |
| Protein Name |
Leucine aminopeptidase 1 EC 3.4.11.- Leucyl aminopeptidase 1 LAP1 Peptidase p2920 |
| Gene Name | lap1 p2920 |
| Organism | Trichoderma harzianum (Hypocrea lixii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Hypocreaceae Trichoderma Trichoderma harzianum (Hypocrea lixii) |
| Enzyme Sequence | MKFLQTSLIAAALPAALVSGRFVIENEGDNVQLDEPAKYLIELSPGETQWVTEEDKWDLRRNGQNFMDITDTQELGTLRAWTQSQASVAFPDKCVKQKEVGELAGHLTKDGMRRNLEKLTSFHTRYYKSDYGRQSSEWVLERINGIIKDAGAEDTVTAEHFGHSWPQSSVIARIPGKTNTTVIIGAHQDSINLWLPSILGAPGADDDGSGTVTIMEVFHTLLKAKDVVGGSAPNTVEFHWYSAEEGGLLGSQAIFQSYEKEGRDVKAMLQQDMTGFVQGTEDAGKPESVGVITDFVHPGLTAFIKKVIEEYCSIPWVETKCGYACSDHASASKAGYPSAFVIESAFENSDQHIHGTDDLIKYLSFDHMLEHAKMTLGLVYELAYHDFSSKAVEEPSEL |
| Enzyme Length | 398 |
| Uniprot Accession Number | A4V8W0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.11.- |
| Enzyme Function | FUNCTION: Extracellular aminopeptidase that allows assimilation of proteinaceous substrates. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Glycosylation (1); Metal binding (6); Propeptide (1); Signal peptide (1) |
| Keywords | Aminopeptidase;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Protease;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | INDUCTION: Expressed in presence of glucose, chitin or fungal cell walls. However, lower levels of expression were found on chitin. Also expressed in carbon starvation conditions. {ECO:0000269|PubMed:17415567}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,932 |
| Kinetics | |
| Metal Binding | METAL 187; /note=Zinc 1; /evidence=ECO:0000250; METAL 206; /note=Zinc 1; /evidence=ECO:0000250; METAL 206; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 245; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 272; /note=Zinc 1; /evidence=ECO:0000250; METAL 354; /note=Zinc 2; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |