| IED ID | IndEnz0002016084 |
| Enzyme Type ID | protease016084 |
| Protein Name |
LPS-assembly protein LptD Organic solvent tolerance protein |
| Gene Name | lptD imp ostA yabG b0054 JW0053 |
| Organism | Escherichia coli (strain K12) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12) |
| Enzyme Sequence | MKKRIPTLLATMIATALYSQQGLAADLASQCMLGVPSYDRPLVQGDTNDLPVTINADHAKGDYPDDAVFTGSVDIMQGNSRLQADEVQLHQKEAPGQPEPVRTVDALGNVHYDDNQVILKGPKGWANLNTKDTNVWEGDYQMVGRQGRGKADLMKQRGENRYTILDNGSFTSCLPGSDTWSVVGSEIIHDREEQVAEIWNARFKVGPVPIFYSPYLQLPVGDKRRSGFLIPNAKYTTTNYFEFYLPYYWNIAPNMDATITPHYMHRRGNIMWENEFRYLSQAGAGLMELDYLPSDKVYEDEHPNDDSSRRWLFYWNHSGVMDQVWRFNVDYTKVSDPSYFNDFDNKYGSSTDGYATQKFSVGYAVQNFNATVSTKQFQVFSEQNTSSYSAEPQLDVNYYQNDVGPFDTRIYGQAVHFVNTRDDMPEATRVHLEPTINLPLSNNWGSINTEAKLLATHYQQTNLDWYNSRNTTKLDESVNRVMPQFKVDGKMVFERDMEMLAPGYTQTLEPRAQYLYVPYRDQSDIYNYDSSLLQSDYSGLFRDRTYGGLDRIASANQVTTGVTSRIYDDAAVERFNISVGQIYYFTESRTGDDNITWENDDKTGSLVWAGDTYWRISERWGLRGGIQYDTRLDNVATSNSSIEYRRDEDRLVQLNYRYASPEYIQATLPKYYSTAEQYKNGISQVGAVASWPIADRWSIVGAYYYDTNANKQADSMLGVQYSSCCYAIRVGYERKLNGWDNDKQHAVYDNAIGFNIELRGLSSNYGLGTQEMLRSNILPYQNTL |
| Enzyme Length | 784 |
| Uniprot Accession Number | P31554 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Contributes to n-hexane resistance. {ECO:0000255|HAMAP-Rule:MF_01411, ECO:0000269|PubMed:12207697, ECO:0000269|PubMed:12724388, ECO:0000269|PubMed:16861298, ECO:0000269|PubMed:18424520, ECO:0000269|PubMed:20203010, ECO:0000269|PubMed:21339611, ECO:0000269|PubMed:2547691, ECO:0000269|PubMed:7811102}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (36); Chain (1); Disulfide bond (2); Helix (10); Mutagenesis (1); Signal peptide (1); Turn (7) |
| Keywords | 3D-structure;Cell outer membrane;Direct protein sequencing;Disulfide bond;Membrane;Reference proteome;Signal |
| Interact With | P0ADV1; P0ADC1 |
| Induction | INDUCTION: Constitutively expressed. {ECO:0000269|PubMed:14981317}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-Rule:MF_01411, ECO:0000269|PubMed:12207697, ECO:0000269|PubMed:12724388, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:20446753}. |
| Modified Residue | |
| Post Translational Modification | PTM: Contains two intramolecular disulfide bonds. At least one disulfide bond is required for activity, and protein is probably fully oxidized in vivo. |
| Signal Peptide | SIGNAL 1..24; /evidence="ECO:0000255|HAMAP-Rule:MF_01411, ECO:0000269|PubMed:12724388, ECO:0000269|PubMed:9298646" |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4RHB; |
| Mapped Pubmed ID | 15690043; 16606699; |
| Motif | |
| Gene Encoded By | |
| Mass | 89,671 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |