IED Industry Enzyme Database

Detail Information for IndEnz0002016109
IED ID IndEnz0002016109
Enzyme Type ID protease016109
Protein Name Collagenase 3
EC 3.4.24.-
Matrix metalloproteinase-13
MMP-13
Gene Name MMP13
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Enzyme Length 471
Uniprot Accession Number P45452
Absorption
Active Site ACT_SITE 223; /evidence=ECO:0000305|PubMed:23913860
Activity Regulation ACTIVITY REGULATION: Inhibited by TIMP1, TIMP2 and TIMP3. Inhibited by acetohydroxamic acid and other zinc chelators. {ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}.
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269|PubMed:16167086, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:19615667, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:8207000, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:8603731, ECO:0000269|PubMed:8663255, ECO:0000269|PubMed:9065415}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Beta strand (33); Chain (1); Disulfide bond (1); Glycosylation (2); Helix (10); Metal binding (30); Modified residue (1); Motif (1); Mutagenesis (1); Natural variant (7); Propeptide (1); Region (3); Repeat (4); Sequence conflict (3); Signal peptide (1); Turn (4)
Keywords 3D-structure;Calcium;Collagen degradation;Direct protein sequencing;Disease variant;Disulfide bond;Dwarfism;Extracellular matrix;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen
Interact With
Induction INDUCTION: Up-regulated by TNF and IL1B. {ECO:0000269|PubMed:8798568, ECO:0000269|PubMed:9056642}.
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:8576151}. Secreted {ECO:0000269|PubMed:8576151}.
Modified Residue MOD_RES 366; /note=Phosphotyrosine; by PKDCC; /evidence=ECO:0000303|PubMed:25171405
Post Translational Modification PTM: The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro).; PTM: N-glycosylated. {ECO:0000269|PubMed:8576151}.; PTM: Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000269|PubMed:8576151
Structure 3D NMR spectroscopy (3); X-ray crystallography (45)
Cross Reference PDB 1EUB; 1FLS; 1FM1; 1PEX; 1XUC; 1XUD; 1XUR; 1YOU; 1ZTQ; 2D1N; 2E2D; 2OW9; 2OZR; 2PJT; 2YIG; 3ELM; 3I7G; 3I7I; 3KEC; 3KEJ; 3KEK; 3KRY; 3LJZ; 3O2X; 3TVC; 3WV1; 3WV2; 3WV3; 3ZXH; 456C; 4A7B; 4FU4; 4FVL; 4G0D; 4JP4; 4JPA; 4L19; 5B5O; 5B5P; 5BOT; 5BOY; 5BPA; 5UWK; 5UWL; 5UWM; 5UWN; 7JU8; 830C;
Mapped Pubmed ID 10229672; 10386589; 10551873; 10809722; 10966814; 10986281; 11119712; 11577169; 11883937; 11903048; 12009331; 12009332; 12139441; 12192005; 12270924; 12392760; 12426321; 12684035; 12734180; 12878172; 12974393; 1311314; 1326552; 1371271; 14558091; 15067375; 15257288; 15551360; 15640153; 15654517; 15693018; 15734640; 15763932; 15868410; 15944607; 15947272; 15950618; 16005220; 16024014; 16144844; 16331612; 16356191; 16398406; 16507124; 16603129; 16825321; 16877349; 16917496; 16948116; 16984617; 1698775; 17009260; 17033924; 17076612; 17116693; 17138534; 17151781; 17208315; 17311929; 17373717; 17373931; 17395008; 17495113; 17606376; 17607721; 17626252; 17697361; 17724016; 17822788; 17853491; 17876296; 17905570; 18006768; 18091353; 18225566; 18262231; 18289056; 18289383; 18308831; 18366705; 18373849; 18487224; 18528653; 18593949; 18709334; 1874716; 18753468; 18755271; 18971037; 18985055; 18987329; 19094243; 19124506; 19180518; 19185056; 19248099; 19248107; 19248116; 19258954; 19296842; 19301259; 19333684; 19415460; 19422937; 19442604; 19453573; 19494318; 19551542; 19561643; 19562509; 19564415; 19692239; 19779140; 19784544; 19812315; 19821768; 19883500; 19902888; 19913121; 19948051; 20043086; 2005102; 20067416; 20097749; 20131257; 20142769; 20175118; 20196777; 20376807; 20452482; 20463008; 20484597; 20485444; 20506238; 20573369; 20587546; 20615395; 20628086; 20634891; 20667128; 20672350; 20673868; 20683000; 20685652; 20706991; 20857147; 20878060; 20878116; 20936527; 20948207; 21039987; 21048031; 21055468; 21107991; 21142220; 21187486; 21191416; 21205837; 21211511; 21278254; 21339746; 21344378; 21344384; 21370305; 21437966; 21508380; 21539914; 21669521; 21720458; 21849805; 21881840; 21937229; 21938739; 21959927; 22006368; 22017539; 22032644; 22084953; 22095691; 22102411; 22128168; 22153941; 22158614; 22273691; 22327326; 22488635; 22505473; 2253219; 22573319; 22590832; 22610965; 22710194; 22710868; 22722466; 22782903; 22869368; 22950625; 22992737; 23132541; 23162804; 23389849; 23417678; 23465389; 23467939; 23665089; 23732700; 23762330; 23845380; 23847446; 23898086; 24008762; 24023851; 24180431; 24351915; 24360951; 24398989; 24563279; 24599080; 24610617; 24615104; 24704999; 24974940; 25006778; 25166220; 25192810; 25264600; 25330343; 25401159; 2551898; 25527274; 25562781; 25607396; 25609201; 25726157; 25742789; 25749207; 25772251; 25835975; 25846944; 25863779; 25880591; 25948792; 25966777; 25976617; 26092928; 26104765; 26298724; 26305372; 26305549; 26308852; 26362844; 26369384; 26395178; 26447617; 26474296; 26526931; 26583473; 26635116; 26892680; 26934732; 27043283; 27058373; 27084377; 27130394; 27172796; 27245877; 27296149; 27356690; 27367673; 27377745; 27391467; 27555113; 27556690; 27630193; 27751807; 27886420; 27932045; 27956552; 27966948; 28085114; 28128735; 28158191; 28238786; 2834383; 28418842; 28419442; 28447732; 2845110; 28512729; 28559201; 28653849; 28728848; 28766880; 28798419; 28798935; 28816390; 29126436; 29247272; 29996935; 30003735; 30031810; 30191992; 3038863; 30439533; 30575896; 30635366; 30695018; 30710321; 30759432; 30889876; 30941969; 3095317; 31074012; 31081124; 31129674; 31264811; 31305294; 31331201; 31440816; 31587013; 31640085; 31677173; 31693113; 31841200; 32035950; 3223920; 32767318; 33031905; 33526510; 33572320; 33604811; 33677160; 33892965; 34014552; 34050742; 34145804; 34171070; 34172768; 34452576; 6270089; 7547873; 7669817; 7780967; 7836360; 7890717; 7896811; 8216228; 8463259; 8626565; 8920930; 8999957; 9008168; 9092507; 9115292; 9346290; 9428515; 9578462; 9651395;
Motif MOTIF 94..101; /note=Cysteine switch; /evidence=ECO:0000250
Gene Encoded By
Mass 53,820
Kinetics
Metal Binding METAL 96; /note="Zinc 2; in inhibited form"; /evidence="ECO:0000250"; METAL 128; /note="Calcium 1"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 162; /note="Calcium 2; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 172; /note="Zinc 1; via tele nitrogen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 174; /note="Zinc 1"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 179; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 180; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 182; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 184; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 187; /note="Zinc 1; via tele nitrogen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 194; /note="Calcium 2; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 196; /note="Calcium 2; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 198; /note="Calcium 2"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 200; /note="Zinc 1; via pros nitrogen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 202; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 203; /note="Calcium 1"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 205; /note="Calcium 1; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 205; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 222; /note="Zinc 2; via tele nitrogen; catalytic"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 226; /note="Zinc 2; via tele nitrogen; catalytic"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 232; /note="Zinc 2; via tele nitrogen; catalytic"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 240; /note="Zinc 2; via carbonyl oxygen; catalytic"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860"; METAL 291; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 293; /note="Calcium 5; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 335; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 337; /note="Calcium 5; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 383; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 385; /note="Calcium 5; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 432; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"; METAL 434; /note="Calcium 5; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305"
Rhea ID
Cross Reference Brenda 3.4.24.17;3.4.24.35;3.4.24.65;3.4.24.B4;