| IED ID | IndEnz0002016111 |
| Enzyme Type ID | protease016111 |
| Protein Name |
Stromelysin-3 ST3 EC 3.4.24.- Matrix metalloproteinase-11 MMP-11 |
| Gene Name | mmp11 |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MHLLILLPALCVLGAHSAPLSYTYLQHRIQEKPQKDHGRLQFNSLHYPHIKGLLNAHGSWNPPRCGVPDIPAPPDSSSGRNRQKRFVLSGGRWDKTNLTYKIIRFPWQLSKVKVRRTIAEALKVWSEVTPLTFTEVHEGRSDIIIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDEAWTIGNNIGTDLLQVAAHEFGHMLGLQHSSISKSLMSPFYTFRYPLSLSADDKHGIQFLYGAPRPPTPSPTPRVEVNQVENESNEIPAAEPDACKTNFDAVSTIRGELFFFKSGYVWRLRGGKLQNGYPALASRHWRGIPDTVDAAFEDSVGNIWFFYGSQFWVFDGKLQASGPFPITDIGISVTQIQAAFVWGTEKNKKTYLFRGGEYWRFNPETRRVESRHSRRIGDWRGVPKGIDAAFQDEQGYAYFVKGRQYWKFDPFKVRVMDGYPHLISQDFFNCQASSTFVNSLR |
| Enzyme Length | 477 |
| Uniprot Accession Number | Q11005 |
| Absorption | |
| Active Site | ACT_SITE 204; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: May be involved in the modification of the extracellular matrix during metamorphic apoptosis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (1); Metal binding (12); Propeptide (1); Region (1); Repeat (4); Signal peptide (1) |
| Keywords | Calcium;Cleavage on pair of basic residues;Collagen degradation;Disulfide bond;Extracellular matrix;Hydrolase;Metal-binding;Metalloprotease;Protease;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 54,442 |
| Kinetics | |
| Metal Binding | METAL 65; /note=Zinc 2; in inhibited form; METAL 152; /note=Zinc 1; /evidence=ECO:0000250; METAL 154; /note=Zinc 1; /evidence=ECO:0000250; METAL 159; /note=Calcium; /evidence=ECO:0000250; METAL 160; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 162; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 164; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 167; /note=Zinc 1; /evidence=ECO:0000250; METAL 180; /note=Zinc 1; /evidence=ECO:0000250; METAL 203; /note=Zinc 2; catalytic; METAL 207; /note=Zinc 2; catalytic; METAL 213; /note=Zinc 2; catalytic |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.B3; |