| IED ID |
IndEnz0002016121 |
| Enzyme Type ID |
protease016121 |
| Protein Name |
Cystatin-C
Cystatin-3
Gamma-trace
Neuroendocrine basic polypeptide
Post-gamma-globulin
|
| Gene Name |
CST3 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
| Enzyme Length |
146 |
| Uniprot Accession Number |
P01034 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (4); Chain (1); Disulfide bond (2); Helix (3); Modified residue (1); Motif (1); Mutagenesis (1); Natural variant (2); Signal peptide (1); Site (1); Turn (1) |
| Keywords |
3D-structure;Age-related macular degeneration;Amyloid;Amyloidosis;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Signal;Thiol protease inhibitor |
| Interact With |
P05067; Itself |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20189825}. |
| Modified Residue |
MOD_RES 43; /note=Phosphoserine; by FAM20C; /evidence=ECO:0000269|PubMed:26091039 |
| Post Translational Modification |
PTM: The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21. {ECO:0000269|PubMed:19838169}. |
| Signal Peptide |
SIGNAL 1..26; /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:6283552, ECO:0000269|PubMed:6365094, ECO:0000269|PubMed:6662498" |
| Structure 3D |
X-ray crystallography (10) |
| Cross Reference PDB |
1G96;
1R4C;
1TIJ;
3GAX;
3NX0;
3PS8;
3QRD;
3S67;
3SVA;
6ROA;
6RPV;
|
| Mapped Pubmed ID |
10391242;
10411933;
10583407;
10993992;
11074789;
11401442;
11467836;
11468325;
11681790;
11711204;
11750287;
11865157;
118839;
12038606;
12101112;
12479412;
12483523;
12589965;
12663624;
12670666;
1270801;
12738401;
12758063;
12787072;
12938144;
14672279;
14714581;
14726415;
15013312;
15034766;
15037657;
15122877;
15174051;
15212828;
15223845;
15312769;
15336605;
15350470;
15479453;
15719405;
15728313;
15829557;
15832773;
15860739;
15882666;
15962837;
16005452;
16049933;
16131730;
16188386;
16213753;
16386559;
16437581;
16443201;
16446102;
16481598;
16608402;
16612982;
16640527;
16713569;
16838182;
16979980;
17130480;
17192785;
17210589;
17310123;
17353786;
17394021;
17470433;
17537416;
17552057;
17636214;
17660266;
17668246;
17718592;
17728092;
17822797;
17826782;
17852800;
17852801;
17901710;
17903292;
17963746;
17998865;
18026100;
18026102;
18044340;
18089366;
18187137;
18216060;
18280806;
18307033;
18314113;
18317874;
18319326;
18356552;
1837051;
18373213;
18376131;
18408364;
18418694;
18449172;
18454664;
18461289;
18484335;
1849145;
18496846;
18508448;
18511756;
18594189;
18667743;
18674527;
18703370;
18713542;
18804033;
18815241;
18824671;
18830724;
18949742;
18953178;
19119287;
19137579;
19151417;
19252175;
19293566;
19357259;
19359536;
19394726;
19403428;
19419268;
19436062;
19446036;
19517296;
19523634;
19597297;
19597298;
19601795;
19636441;
19674067;
19741512;
19765773;
19774637;
19808324;
19816197;
19819453;
19861863;
19915865;
19929276;
19938052;
20052346;
20132026;
20157249;
20175878;
20353367;
20399428;
20413850;
20450259;
20468060;
20482807;
20489688;
20502295;
20534741;
20538834;
20574650;
20576828;
20692472;
20699092;
20711500;
20802417;
20806899;
20807650;
20809110;
20849835;
20858959;
20879967;
20880607;
20882990;
20885369;
20921817;
20923994;
20926009;
20980977;
21069389;
21074623;
21094842;
21112096;
21115625;
21143385;
21151566;
2118650;
21187262;
21198422;
21274315;
21286018;
21315176;
21388623;
21415918;
21470355;
21494031;
21518160;
2153254;
21577020;
21617716;
21619490;
21697790;
21700821;
21710343;
21723753;
21757984;
21782177;
21784814;
21795086;
21852668;
21861242;
21927796;
21928225;
2195544;
22008011;
22057131;
22057374;
22072023;
22117908;
22139178;
22207347;
22209964;
22228436;
22267378;
22278599;
22287159;
22305809;
22307441;
22315498;
22322818;
22349874;
22380485;
22426688;
22435454;
22467317;
22474211;
22515481;
22547045;
22622496;
22626587;
22663994;
22669102;
22674847;
22705926;
22710694;
22809763;
22818840;
22837540;
22844527;
22884092;
22898924;
22899766;
22947524;
22978689;
23000961;
23008697;
23026592;
23070277;
23089714;
23093662;
23095576;
23111743;
23142864;
23179198;
23194995;
23258794;
23300153;
23306163;
23335043;
23347458;
23383156;
23392363;
23396290;
23414098;
23414447;
23423253;
23429977;
23479071;
23518194;
23519666;
23574755;
23580616;
23594833;
23629649;
23629651;
23650620;
23670303;
23684135;
23698027;
23698074;
23701892;
23706287;
23835667;
23836469;
23849305;
23852792;
23893055;
23912790;
23932088;
23945244;
23987825;
24028541;
2409350;
24101592;
24178809;
24202134;
24216017;
24254896;
24295505;
24365793;
24376511;
24384771;
24405645;
24405769;
24409073;
24421217;
24465871;
24470529;
24471722;
24492354;
24500719;
24522084;
24606172;
24652630;
24661756;
24704396;
24725853;
24734782;
24790080;
24821156;
24914379;
24925313;
24963810;
24979323;
25074643;
25084128;
25155186;
25182044;
25194959;
25216761;
25230103;
25265151;
25300191;
25344529;
25367815;
25402375;
25479090;
25589536;
25629773;
25654627;
25663560;
25697425;
25727405;
25736604;
25832128;
25863806;
25893795;
25911852;
25932809;
25944130;
26024878;
26115583;
26185434;
26191245;
26194503;
26215986;
26354502;
26356356;
26396066;
26402227;
26427030;
26498756;
26576434;
26584598;
26592151;
26629900;
26632077;
26642700;
26710332;
26757339;
26845025;
26865059;
26897077;
26904684;
27010456;
27012045;
27012051;
27020372;
27079462;
27087511;
27125433;
27190304;
27208743;
27414726;
27548357;
27573935;
27578255;
27658322;
27680774;
27714883;
27743042;
27862029;
27889768;
279930;
28067897;
28078200;
28142264;
28143410;
28182342;
28182344;
28189145;
28272253;
28321013;
28332367;
28372557;
28417217;
28487367;
28545169;
28552392;
28586363;
28599259;
28630039;
28633877;
28763843;
28778467;
28812020;
28830298;
28865325;
28922364;
28937056;
2900981;
29046353;
29086660;
29090609;
29179178;
29249381;
29355583;
29627485;
29654808;
29661604;
29673928;
29684685;
29722001;
29724997;
29749360;
29778943;
29789781;
29792017;
29870981;
29891036;
30024915;
30033802;
30035656;
30284299;
3035556;
30460495;
30484377;
30517681;
3053705;
30610366;
30639197;
30640054;
30643006;
30805744;
3080684;
30848029;
30871390;
30874448;
30890820;
3094007;
31054924;
31096818;
31115219;
31119598;
31189155;
31189973;
31313057;
31317040;
31330077;
31342824;
31353156;
3142462;
31601879;
31606750;
31686541;
31709845;
31755786;
31828903;
31979726;
32050196;
32062670;
32150034;
32165608;
32170118;
32281037;
32306911;
32401159;
32438638;
32447504;
32481372;
32586317;
32616516;
32648717;
32664054;
32716587;
32750487;
32757062;
32799396;
32924598;
33017825;
33058496;
33061826;
33068572;
33172965;
33207943;
33388409;
33431697;
33601303;
33723337;
33727514;
33832138;
33843816;
34019155;
34037438;
34234738;
34397720;
34404134;
34413410;
34571286;
34676572;
34789194;
34867965;
8097946;
8159701;
8464497;
8490014;
8870004;
9006323;
9054935;
9862427;
|
| Motif |
MOTIF 81..85; /note=Secondary area of contact |
| Gene Encoded By |
|
| Mass |
15,799 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|