| IED ID | IndEnz0002016136 |
| Enzyme Type ID | protease016136 |
| Protein Name |
F-box/SPRY domain-containing protein 1 F-box synaptic protein 1 |
| Gene Name | fsn-1 C26E6.5 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MAENDGETIVPDEQCNLTASTPMKSSGLEQVESPKERKTSMVECDDEGNPSSGTPDESPKQLTPHSIPPRRRRSPRRPEVSASRLPLKVLNQIFQYLPLKDLRSAMLTCHSWNNALSMEDSDIWQYLLGKKLPEAAVSDPFLLAELGSAKKKLRAWYFAWNTSDISRNNYIRTNGFTVHRQPVAQSTDGVRGKRGISKGVHAFDITWDGPLGTVAVVGIATKHAALHCVGYVALLGSDDQSWGWNLVDNVLMHNGAQLGVYPKMNNPPKYEVGDKIRLIIDCDTHVAYFERNSEFLGIAFNHIPPLRLYPAVCAVYGNTEVTMVYVGSPQMG |
| Enzyme Length | 332 |
| Uniprot Accession Number | Q18223 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons (PubMed:15208641, PubMed:23665919). Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles (PubMed:23665919). By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing (PubMed:23665919). May stabilize synapse formation by promoting the down-regulation of scd-2 (PubMed:15208641). Regulates axon termination in PLM and ALM neurons (PubMed:21968191). {ECO:0000269|PubMed:15208641, ECO:0000269|PubMed:21968191, ECO:0000269|PubMed:23665919}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein ubiquitination. |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Domain (2); Mutagenesis (1); Region (1) |
| Keywords | Cell junction;Direct protein sequencing;Reference proteome;Synapse;Ubl conjugation pathway |
| Interact With | G5ECU1 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell junction, synapse. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 11864566; 16049479; 18340346; 18692475; 19123269; 19164707; 19372390; 21085631; 21177967; 22267497; 22560298; 23800452; 24810406; 24884423; 25326385; 25487147; 26464359; 27979965; 29997255; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,825 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |