| IED ID | IndEnz0002016206 |
| Enzyme Type ID | protease016206 |
| Protein Name |
Serine protease inhibitor Kazal-type 7 Esophagus cancer-related gene 2 protein ECRG-2 |
| Gene Name | SPINK7 ECG2 UNQ745/PRO1474 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MKITGGLLLLCTVVYFCSSSEAASLSPKKVDCSIYKKYPVVAIPCPITYLPVCGSDYITYGNECHLCTESLKSNGRVQFLHDGSC |
| Enzyme Length | 85 |
| Uniprot Accession Number | P58062 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Probable serine protease inhibitor. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (4); Chain (1); Disulfide bond (3); Domain (1); Helix (2); Signal peptide (1); Site (1) |
| Keywords | 3D-structure;Disulfide bond;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | P16452; O15235; P13640; P80294; P02795; Q3YEC7; Q8IZW4 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | NMR spectroscopy (1) |
| Cross Reference PDB | 2LEO; |
| Mapped Pubmed ID | 12646258; 12970870; 14639608; 17352218; 17418617; 17602171; 17693286; 18162463; 18618216; 18824154; 19717562; 19796867; 21042721; 22315007; 26434587; 28348485; 28852849; 29875205; 32681017; 33767253; |
| Motif | |
| Gene Encoded By | |
| Mass | 9,232 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |