| IED ID |
IndEnz0002016241 |
| Enzyme Type ID |
protease016241 |
| Protein Name |
Olfactomedin-like protein 3
|
| Gene Name |
olfml3 |
| Organism |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amphibia
Batrachia
Anura
Pipoidea
Pipidae
Xenopodinae
Xenopus
Silurana
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
|
| Enzyme Sequence |
MAGIVACILLVFVTVITAQQQAVFLEYIQGRMGVLEERLSQWHDQSSRYSGELRDFKNQVLKMLENIEKERESLRNEMENTNVRVDRLEREVDYIETQNPAPPCVEIDEKLTELHDAKKKKKEKYEKITGCPAADIPGKEETDEILIPPVIRKPYCSDTISQVTAMKILKRFGSSAGLWTKDLAGNSDRIYVFDGAGNDTVYVYPRMKEFTLSSSTRKAAKIKLPFPWIGTGHIVYDGNLYYIRQDNEFQVIKFNLANKTIIDSAVLPIEQQVPVYGLSKFNYIDIVADEEGLWVIYATKENEKNICLAKLDPSSLSIEQMWDTPCPIENAESAFVVCGSLYVVYNTKLPSRSRIQCVFDVSGTISSENVPIVYFPKRYGSHSSMKYNPKEKQIYAWDDGYQMLYKLNMKHRDELY |
| Enzyme Length |
416 |
| Uniprot Accession Number |
Q0V9V5 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1 (By similarity). {ECO:0000250}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Coiled coil (1); Disulfide bond (1); Domain (1); Glycosylation (2); Signal peptide (1) |
| Keywords |
Coiled coil;Developmental protein;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
47,756 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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