| IED ID | IndEnz0002016272 |
| Enzyme Type ID | protease016272 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | ddi1 NFIA_027290 |
| Organism | Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Aspergillus fischeri Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus) |
| Enzyme Sequence | MTVELLKAIVESETSIPTNNQRLVYNNQLLGNDAQTLEQIGIGEGDMLGVHVTMRSPQAPARSIGGGPSAAAQQNLQRRQPMTPDPETIRLHILGDPRVREAVRRQNPELADAANDAQRFRDVLMAQQRREAQMEAEKEARIAMLNADPFNPENQREIEEIIRQNAVTENLHTAMEHHPESFGRVTMLYIPVEVNGHKVNAFVDSGAQVTIMSPECATACNIMRLVDRRYGGIAKGVGTATILGRVHSAQIKIGSMFLPCSFTVMEGKHIDLLLGLDMLKRHQACIDLKKGALVIQDEAVPFLGEADIPKELQEGFEDEPIVKGADGAEVGARTGAVTHQASGPGTSAAAPSSSTPRINIRPAPSSRWPQDSIAKITELGFTREEAVRALDAANGDLDGAIGFLI |
| Enzyme Length | 405 |
| Uniprot Accession Number | A1DCU5 |
| Absorption | |
| Active Site | ACT_SITE 204; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (2); Domain (2); Region (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,932 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |