| IED ID | IndEnz0002016275 |
| Enzyme Type ID | protease016275 |
| Protein Name |
Mite allergen Der f 6 EC 3.4.21.- Allergen Der f VI DF5 allergen Der f 6 |
| Gene Name | DERF6 |
| Organism | Dermatophagoides farinae (American house dust mite) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Acari Acariformes Sarcoptiformes Astigmata Psoroptidia Analgoidea (feather mites) Pyroglyphidae (house-dust mites) Dermatophagoidinae Dermatophagoides Dermatophagoides farinae (American house dust mite) |
| Enzyme Sequence | MIKIFLVTILIVITVTVDARFPRSLQPKWAYLDSNEFPRSKIGDSPIAGVVGGQDADLAEAPFQISLLKDYLIMKRHMCGGSLISESTVVTAAHCTYGQKASSLSVRYGTNQRTSSSYGDLKVKPIIQHESYEQDQTQTDKTIIILPNPVVPSTNVQMNEIETEDIVDGDKVTIYGWGLTDGNGKDLPDKLQKGSMTIVGNDRCNEKWGSINAIHPGMICALDKTQSGCNGDSGGPLVSANRKLTGIVSWGPSKCPPGEYMSVFTRPKYYLDWITKNIV |
| Enzyme Length | 279 |
| Uniprot Accession Number | P49276 |
| Absorption | |
| Active Site | ACT_SITE 94; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 140; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 233; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Protease that shows specificity similar to chymotrypsin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (1); Propeptide (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Allergen;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 30,535 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |