| IED ID | IndEnz0002016304 |
| Enzyme Type ID | protease016304 |
| Protein Name |
Intermediate cleaving peptidase 55 EC 3.4.11.26 |
| Gene Name | icp55 SPAC12B10.05 |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MSGYIRTLFIRNRFSNYRLRSQIIKYKYSNVSYLNKSALRCGQATDSTHPHILQPGELTPRISAQEYKTRRDRVASLLEDNDFMIVTSAPVRHMCGAAFYEYHQDPNFYYLTGCLEPNAVLLMFKNGASGSYDCSLYLPSKNPYIEKWEGLRTGSTLGKKLFQIENVYDSSLASSVINALGKKSNRIFYNYQTGYLSKMPAASAPEFIQDTLTKLFRTSTQRSVDELLHPLRSIKSTAELECMKEAANISSNVYREIMRKRFEKEAEMSAEFNYRFCIGGCDRSAYVPVVAGGKNGLTIHYTINNDIFRPDEMVLVDAGGEFGGYVTDISRTWPINGKFSTVQRDLYQAVLNVQKKCIKYCCTSNGWSLADIHFESVKLMHEELKQVGIHGTKREITDILYPHSIGHEIGLEIHDCSTNNGYQPLRKNQVITIEPGLYVPEEDGWPQWAQGIAIRIEDSVIVGDDKPFVLTSAAPKEIEEIEALKK |
| Enzyme Length | 486 |
| Uniprot Accession Number | Q10439 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=The enzyme cleaves the 36-Pro-Pro-37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.; EC=3.4.11.26; Evidence={ECO:0000250|UniProtKB:P40051}; |
| DNA Binding | |
| EC Number | 3.4.11.26 |
| Enzyme Function | FUNCTION: Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome. {ECO:0000250|UniProtKB:P40051}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (7); Transit peptide (1) |
| Keywords | Aminopeptidase;Hydrolase;Manganese;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Protease;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16823372}; Peripheral membrane protein {ECO:0000269|PubMed:16823372}; Matrix side {ECO:0000269|PubMed:16823372}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20473289; 23697806; |
| Motif | |
| Gene Encoded By | |
| Mass | 55,141 |
| Kinetics | |
| Metal Binding | METAL 317; /note=Manganese 2; /evidence=ECO:0000255; METAL 328; /note=Manganese 1; /evidence=ECO:0000255; METAL 328; /note=Manganese 2; /evidence=ECO:0000255; METAL 407; /note=Manganese 1; /evidence=ECO:0000255; METAL 434; /note=Manganese 1; /evidence=ECO:0000255; METAL 457; /note=Manganese 1; /evidence=ECO:0000255; METAL 457; /note=Manganese 2; /evidence=ECO:0000255 |
| Rhea ID | |
| Cross Reference Brenda |