| IED ID | IndEnz0002016320 |
| Enzyme Type ID | protease016320 |
| Protein Name |
Integrin alpha-V Vitronectin receptor Vitronectin receptor subunit alpha CD antigen CD51 Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain |
| Gene Name | ITGAV MSK8 VNRA VTNR |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET |
| Enzyme Length | 1048 |
| Uniprot Accession Number | P06756 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 260..268; /evidence="ECO:0000255, ECO:0000269|PubMed:28117447"; CA_BIND 314..322; /evidence="ECO:0000255, ECO:0000269|PubMed:28117447"; CA_BIND 379..387; /evidence="ECO:0000255, ECO:0000269|PubMed:28117447"; CA_BIND 443..451; /evidence="ECO:0000255, ECO:0000269|PubMed:28117447" |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (89); Calcium binding (4); Chain (3); Disulfide bond (9); Erroneous initiation (1); Glycosylation (13); Helix (9); Motif (1); Natural variant (3); Region (1); Repeat (7); Sequence conflict (3); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (9) |
| Keywords | 3D-structure;Alternative splicing;Calcium;Cell adhesion;Cell junction;Cell membrane;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;Glycoprotein;Host cell receptor for virus entry;Host-virus interaction;Integrin;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | P05106; P18084; P18564; Q38SD2-2; P17612; P54725; P50454; P37173 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..30; /evidence=ECO:0000269|PubMed:2467745 |
| Structure 3D | Electron microscopy (11); X-ray crystallography (21) |
| Cross Reference PDB | 1JV2; 1L5G; 1M1X; 1U8C; 3IJE; 4G1E; 4G1M; 4MMX; 4MMY; 4MMZ; 4O02; 4UM8; 4UM9; 5FFG; 5FFO; 5NEM; 5NER; 5NET; 5NEU; 6AVQ; 6AVR; 6AVU; 6DJP; 6MK0; 6MSL; 6MSU; 6NAJ; 6OM1; 6OM2; 6UJA; 6UJB; 6UJC; |
| Mapped Pubmed ID | 10025398; 10358769; 10640428; 10982404; 11158588; 11724803; 11848444; 11858476; 11872628; 11877390; 11884718; 11928818; 11934894; 11959660; 11970960; 12031826; 12099514; 12143051; 12161360; 12168086; 12198771; 12210725; 12237112; 12237321; 12270930; 12324452; 12324470; 12358597; 12364323; 12370491; 12372469; 12372811; 12399420; 12415008; 12423238; 12427871; 12486108; 12553378; 12639965; 12642872; 12645863; 12660257; 12682293; 12691260; 12750158; 12765524; 12820653; 12874388; 12875973; 12893184; 14524530; 14666169; 14715956; 14741360; 14766759; 14966135; 15044441; 15269586; 15299032; 15345499; 15479743; 15509546; 15557124; 15609323; 15638730; 15647827; 15695828; 15795319; 15828940; 15834425; 15866865; 1588291; 15897908; 15899827; 15914035; 15921657; 15925879; 15998788; 16005200; 16024014; 16051604; 16099422; 16100012; 16105876; 16150802; 16186116; 16400188; 16407244; 16413178; 16448724; 16496302; 16614246; 16631740; 16631833; 16672769; 16675963; 16702213; 16720645; 16731529; 16760434; 16790523; 16818691; 16835373; 16877343; 1694173; 16945929; 16947382; 1697296; 16973584; 17030947; 17034033; 17175151; 17275949; 17300927; 17314405; 17331499; 17369840; 17446174; 17483236; 17550972; 17615072; 17621633; 17641225; 17854909; 17879163; 17965016; 17968485; 18062611; 18064530; 18079201; 18084301; 18090124; 18191107; 18211678; 18221819; 18227168; 18247041; 18268517; 18310319; 18331351; 18331591; 18345483; 18349127; 18353318; 18353785; 18357713; 18364349; 18394009; 18427826; 18445685; 18451156; 18549690; 18550570; 18555990; 18648521; 18694400; 18695916; 18698261; 18781095; 18814143; 18821851; 18844213; 18854176; 19017937; 19037107; 19061491; 19074851; 19088289; 19118218; 19164533; 1918072; 19212436; 19212638; 19255147; 19267182; 19267251; 19334037; 19371633; 19435649; 19448673; 19463016; 19475568; 19487690; 19502598; 19541645; 19549907; 19581046; 19617625; 19695571; 19704023; 19710103; 19738201; 19751734; 19808093; 19808644; 19811096; 19815712; 19818132; 19837659; 19882657; 19888429; 19888537; 19889638; 19910644; 19913121; 19998373; 20019187; 20026907; 20033473; 20121756; 20158572; 20217867; 20224109; 20306691; 20379614; 20400979; 20477989; 20519501; 20554778; 20558745; 20600001; 20605574; 20626753; 20628086; 20628624; 20638909; 20639902; 20672329; 20715172; 20719960; 20826760; 20837477; 20838674; 20857483; 20942236; 20945385; 20972812; 21037076; 21098231; 21116829; 21135163; 21150164; 21178476; 21182210; 21283814; 21321266; 21321268; 21344378; 21347514; 21352421; 21375561; 21379327; 21425129; 21427239; 21433063; 21530503; 21642437; 21646718; 21677875; 21712047; 21748756; 21752283; 21764795; 21787362; 21853313; 21957301; 21978494; 22081074; 22081516; 22094875; 22110279; 22132110; 22134916; 22174124; 22308022; 22469980; 22539938; 22547930; 22566688; 22659470; 22710795; 22719931; 22787119; 22837212; 22879933; 22884367; 22966907; 22975325; 23022044; 23028753; 23053782; 23106217; 23119061; 23128103; 23150579; 23161541; 23181508; 23204516; 23227240; 23238957; 23261238; 23269786; 23283986; 23331428; 23386126; 23397142; 23412966; 23462327; 23615713; 23618859; 23650620; 23704872; 23722547; 23725446; 23726972; 23744557; 23776077; 23821196; 23840404; 23845472; 23845726; 23898055; 23992637; 24023288; 2412224; 24150233; 2420006; 24294359; 24363825; 24389192; 24412187; 24424369; 24464580; 24478423; 24498405; 24515920; 24573955; 24639195; 24658351; 24690239; 24692540; 24695839; 24699825; 24737028; 24737780; 24785587; 24789099; 24939290; 25063885; 25117682; 25150077; 25150423; 25174803; 25193465; 25249331; 25263164; 25273699; 25275062; 25277122; 25290158; 25318615; 25320004; 25370835; 25383667; 25488971; 25497015; 25572981; 25604835; 25663698; 25745053; 25749383; 25849225; 25857463; 25858144; 25862865; 25889845; 25982998; 26157134; 26165836; 26222911; 26334633; 26496610; 26514956; 26621838; 26663660; 26719354; 26846197; 26901152; 26902100; 26918452; 27003228; 27076771; 27108184; 27128974; 27145276; 27233075; 27248172; 27279620; 27283740; 27363302; 27420801; 27466481; 27476161; 27553273; 27593923; 27606892; 27695111; 27769864; 27782111; 27819680; 27864802; 27906177; 27927700; 27929116; 27974569; 28086938; 28314844; 28376277; 28484027; 28534487; 28646039; 28650456; 28682441; 28695371; 28730778; 28943429; 29033288; 29097183; 29152665; 29184982; 29282362; 29453316; 29577899; 29603594; 29743605; 29882028; 30049512; 30061598; 30074214; 30333317; 30355650; 30359079; 30367545; 30472097; 30486830; 30552383; 31033358; 31199988; 31243731; 31285770; 31319863; 31353240; 31366904; 31429823; 31792290; 31904487; 31910058; 31955848; 31956038; 31964886; 32107949; 32113856; 32164941; 32248791; 32450701; 32681389; 32819225; 32964955; 32988382; 33068727; 33069505; 33079476; 33404190; 33693877; 33750829; 34161337; 34174926; 34440692; 34502434; 7505120; 7525578; 7532190; 7542249; 7542669; 7559467; 7678924; 7685013; 7693733; 8617364; 8798654; 8838667; 9251239; 9361014; 9367446; 9396761; 9443892; 9725916; 9763615; 9858236; 9949188; |
| Motif | MOTIF 1019..1023; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 116,038 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |