| IED ID | IndEnz0002016352 |
| Enzyme Type ID | protease016352 |
| Protein Name |
Lon protease homolog 2, peroxisomal EC 3.4.21.53 |
| Gene Name | lonp2 zgc:92557 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MSSNSGIQIPSRLPLLCTHDGVLLPGSTMRVSVDTARNMQLVKSRLLKGTSLKSTIIGVIPNTRDPEHDSDELPSLHSIGTAGLAVQVVGSNWPKPHYTLLITGLCRFRVSQLLRERPFPVAEVEQLDKLEQYTEGDPADGELGELSQRFYQAAVQLVGMLDMSVPVVAKLRRLLDSLPKETLPDVLAAMIRTSNKEKLQVLDAVDLEERFKKALPLLTRQIEGLKLLQKTRKLRPDDDKRVLSIRKGGVFPGRQFSLDEEVEDEDSDDTALLERKVKAAAMPEAALRVCLKELRRLKKMPQSMPEYALTRNYLEMMVELPWSKSTTDCLDIRAARVLLDNDHYAMEKLKKRVLEYLAVRQLKSTLKGPILCFVGPPGVGKTSVGRSIARTLGREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKSLQGDPAAALLEVLDPEQNHSFTDHYLNVPFDLSQVLFIATANTTATIPPALLDRMEVLQVPGYTQEEKVEIAHRHLIPHQLEQHGLTPQQLQIPQDTTLQIISKYTREAGVRSLERKIGAVCRAVAVKVAEGQKVSRSEAPTEQHAEQNTDSKVEDSGIAAPPEMPIVIDHVALKDILGPPLFEMEVSERLTLPGVAIGLAWTPMGGEIMFVEASRMEGEGQLTLTGQLGDVMKESAHLAISWLRSNAKTYLLNDGSADLLEGTDIHLHFPAGAVTKDGPSAGVTIVTCLASLLSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRANLKRIIIPKRNEKDLEEIPANVRADLDFVLAGTLDEVLNAAFDGGFPSAVNHPQVLSKL |
| Enzyme Length | 840 |
| Uniprot Accession Number | Q5PQY6 |
| Absorption | |
| Active Site | ACT_SITE 731; /evidence=ECO:0000255|HAMAP-Rule:MF_03121; ACT_SITE 774; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03121}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. {ECO:0000255|HAMAP-Rule:MF_03121}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 375..382; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Features | Active site (2); Chain (1); Compositional bias (1); Domain (2); Motif (1); Nucleotide binding (1); Region (1) |
| Keywords | ATP-binding;Hydrolase;Nucleotide-binding;Peroxisome;Protease;Reference proteome;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000255|HAMAP-Rule:MF_03121}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 838..840; /note=Microbody targeting signal; /evidence=ECO:0000255|HAMAP-Rule:MF_03121 |
| Gene Encoded By | |
| Mass | 92,221 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |