| IED ID | IndEnz0002016359 |
| Enzyme Type ID | protease016359 |
| Protein Name |
Metacaspase-3 EC 3.4.22.- PfMCA3 |
| Gene Name | MCA3 PF3D7_1416200 |
| Organism | Plasmodium falciparum (isolate 3D7) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Laverania) Plasmodium falciparum Plasmodium falciparum (isolate 3D7) |
| Enzyme Sequence | MVYNNGSLRGRKKIEEKYIPMNRKSTSLKDPSRTKNNNYIKTLDTYINEEDSPTKILSKGKKNKNENIKKRINEKDNDTDREDAASLNVDYNKNVMKKYNTRGTFIEKVSSSERNIEHNNNIIRKLGSKDYSKARVQTMTTNIGNHNALKKINPKVPSITSRTKSYTKVMNENKYNNNNSNNSNNNNINSMYYSKKLNNKKYSTEHTQSIDNNNITSKRLNNKKTATDKAQSTSRYCISNSVKKSYSTKGYNTDRSQTMSRYTLQNKKDSNTNTNRKGYSTHRGQIIQDNSNINNQAEKKKRNMSLKKKYIKESSNSTITGSNEKKNSNNILKKNSTCDLNYLNKEYNNNNNMHEHAENVYNINDNEGCSSMQIINDEDVQKNVPEFYTINLGSETKNMGENYIFKNRDKKIKPNIYNERNNMDLMEHKLNDDMSYNFADHIKDIECYINQLNESNKCNIYKECDPSKLISPVYDNVNDNILENNQQLNEYEKHNDILTTSYLKYYSHTNNNNHYYNDEDVHLDLGKTNEGFSNVVKNMDNIPWNETNKKESFSNIKKKIDHTDDRHIAYVDNSSMKHTMNDKDQYVKNVPYNNTMEEVLLLNEKRGNILGSLISKNHDAKRATSNNNNINNNKYYYYDNKYSEHGGDSVSSNIGYPHGYKNNNIYNYVNNIKDLSSPLYCNTKTKRAHKFHTDNIMSDQLNKYEDNNKNDGKFFSGNISSKQKGKNNLTNYTTHSSEYRIKSIESNLTKDYRKSLTYNDIPNFLDYNINNTNVQNSDFGDSHYINRNVSYKNSMNSNDDIQNSNNNNNNNNNNNMVNNPNEYLVYTNEKHYVRINNKLYEKTRDNTYIEVDSNSNFDIINDINSSHNSPLDNIKDNTLYHNTNKKEYSDYVSSYSNINKYEDINLPNNIHVSKDGKYLFKNYSVSQNVSDDNSVQDSFFSRTERSNSQNRYDKNGVNHIEQNYYNNSNRRDDIYYYHNQLKKLERLTQQNIKSGKYQRNIPQNDDNDHNDDDSEIKEVKKDKTKIDMNKHLHLNDKKIFNQVKRENTGVHMNASKTIKNMKEVTYRNINNDTNYNNNNVKINYLYSDELGKNKNRDTPLKTKQHGDSLDNKTELKKKIYNDIINNDIINNNIINNDIIKSGAINNNIVNNNLINNYNADNRNVSNSIFTQHINNINNNFYNSDDERINIIDNNKRMDMTKDESDRFRNNYFVELEKRKKNLGKTNNTTPISLSKNETINNMMINKRNFFNNYISDKVRDKILKREISCSVNTVCSSKTNNKTNSNYSSNNNNDNNNNNNNSNPFILDNSIRKSNIIITTSNNAKLINNTIISKGINNNILNINSNKNKSLNSAKINALGLLSSRNDLNYIMNNNRTSNNHINQHLLYNNRNYSVIKIPNVHKEKRSSKIPHNINIKSNLNLEPNIKTYTNIKTPINIKAYTNIKAPTNIKAPINIKASTNIKAPTNVKAPTNVKAPTNVKAPTNVNAPTNVNAPTNANAPTYVNTPTNIKRQEFSNVTLNYKGISKFDINEDKNTTIIPPLHRQSNSNFPFKNTKLNLNSDMYTEKELIKCKSINNSDIYNYLRNTYNKTPSKFYRTVSYRNMSLKKNKSMLENRKRKTEKKEENLMSTFNYTSEVDSKYIVKKAVVVGCNYVSEERSRLYGSVNDAYVFCRALVKYFDFLPENILLLTDSLPSNAYIYEDFDINRKKYINVDEEENIKNNEPLKKKNIFNLFNTNALYTTLKKTNEEELNCNSCKDVEIKNVDISSEKMNFNLWPTRVNILKAVNWLVRDSIPFGSYVFYFAGKSVQVDNMSGWEGEGYDEAFLCSDPFNKISEHNVITAVQLKDLLLSINESAQMTIILDCSGGQTILDPAGTENSLSYIKGCKQKGIWPITNPTNKVHKAIYDITILNNTSMKKYFCRSRYSKLIEVESTSAMIDPLLQSISSLPVAPKAYCLCAATWEQISIEGLFPIIEFARVSQLKKPESYKTGEGHYQNMNKKNIRAEKSNRNGPNGLINKNNNLSKKTNYEKNFNFTLNMMKMLFSNTNNNENKLDEKEKINRLGFNENDSDYIDDNYNSDDNNNNNYYYNYDGEKGFKNFQENLNNVGQKDVIKNKKFKDNYILVSHGVFTYCLIEAIIEFKEKELKYNILEKKNEQFIPMTLKNLINVIQQKMQNIKYNKLKKINQKPEFTIHPGANATNNNYFVHYSKNIHFQNYKCNFINADLSPFLNVNKAWEEINRTTLRNRKSLSLSSTLINTASSKYFTQKNEQFKNSYSLKY |
| Enzyme Length | 2280 |
| Uniprot Accession Number | Q8ILT4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease that cleaves specifically after arginine or lysine residues. {ECO:0000269|PubMed:31301397}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 25 degrees Celsius. {ECO:0000269|PubMed:31301397}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5. Has activity up to pH 9.5. {ECO:0000269|PubMed:31301397}; |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Region (7); Site (1) |
| Keywords | Hydrolase;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 264,925 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |