| IED ID | IndEnz0002016381 |
| Enzyme Type ID | protease016381 |
| Protein Name |
A disintegrin and metalloproteinase with thrombospondin motifs adt-1 ADAMTS adt-1 EC 3.4.24.- |
| Gene Name | adt-1 C02B4.1 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MPPFYIVITFLLSTVFRISQSVHHHLNEEELKQVFGVSNKHDVPEYSLIEATRHPLKNGNLKMKFTAWNDTYHLNLRKNSRIVSPHIISVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFLVLQTLPKRVHHLQKERHLVYKRSAGLLTNAESKIREEITRLQEEQESFCDTSEQLDDPAMTIPAHLHFNYTIPTSAQLDSSFIFPNMDPITLEIGLFLDSKLFEHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGVHKNGQAQSLLDAFCRYQAHMNPGTDLTDMNHYDHGVLLTGYDIYHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMGHNMGMVHDGVQNQCNKGCCLMSAVNGAGKTTWSDCSVREFNAFLLQLDESGRGNCLRDASPGLISTNHLSDLRLPGQRFTADQQCSYFWGRDYKVEIPNGKAMDDICRILWCGNSGSTISTAHPALEGSWCGANKWCHKGQCTHWTFGLTPVPIDGEWSEWGGAEKGCPIQQCAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGIVCGATSSNCLGFTREEFGNKICSSIKYDPHKPDQQLTGEGFEHSTQPCRVWCHLIGSELIRNKGQFPDGTPCGFDAYCVGGQCLALSCDNKALVEQPEDCPRIEGRSVHQWEEWSSWSECSVSCGLGGREVRERKCSSGRKCQGVSEESRPCEGVLRDCEEFGEWKEWGSCSEKCALGVQKRFRPCLTDQCSSKHLQEERPCDNEGCWTNWDEWSSCSQSCGGGRRYRIRKCLDDKCDGDDLEKESCNTQKCISQSWGDWLPCSVSCGIGFQIRERLCDGELCATANKQARTCNQQQCPSAFSLSVWSEWGEWTTCSATCGEGLQSRERSCRRGSCTEDDASQTRRCVNGPCEHSYLTWSEWTTCETCSSFDSRKRIAKCDGTTENCQDKIDEETCDIACLREKHSFGPISPRRPKLITSNDLRKAFGRPLLPIESIHSEKWSEWGPCSVTCGSGRRVRTRGCQEASCPEQHIQTEECNLNSCLELFIWSDWSSCSKSCGQDGIQTRQKLCLFNNAECSSYAESRRCKDLPSCSSISSGRTISENGFDAPRWSEWSSWSACSCFSLTSTRRRFCQVVDPTVQGFCAGAILEQIPCAPGSCSPSAGGWSLWSEWSSCSKDCGDTGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDNVCSDEKVDGGWTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPARCHLRDGGWSTWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQSCSGLAHQTSLCDLPACDHESDGEWSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSPSTALCSSFITSSHLADGYFIDTDQQQ |
| Enzyme Length | 1461 |
| Uniprot Accession Number | G5ECS8 |
| Absorption | |
| Active Site | ACT_SITE 389; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle. {ECO:0000269|PubMed:11796737}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (25); Domain (15); Glycosylation (2); Metal binding (3); Motif (1); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 11997343; 21177967; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | MOTIF 190..197; /note=Cysteine switch; /evidence=ECO:0000250|UniProtKB:P03956 |
| Gene Encoded By | |
| Mass | 162,616 |
| Kinetics | |
| Metal Binding | METAL 388; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 392; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 398; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Rhea ID | |
| Cross Reference Brenda |