| IED ID | IndEnz0002016397 |
| Enzyme Type ID | protease016397 |
| Protein Name |
Non-toxic nonhemagglutinin type E NTNHA Botulinum neurotoxin type E non-toxic component |
| Gene Name | |
| Organism | Clostridium butyricum |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Clostridia Eubacteriales Clostridiaceae Clostridium Clostridium butyricum |
| Enzyme Sequence | MKINGNLNIDSPVDNKNVAIVRSRNQMFFKAFQVAPNIWIAPERYYGESLKINEDQKSDGGIYDSNFLSTNNEKDEFLQATIKLLQRINNNVVGAKLLSLISTAIPFPYENNTEDYRQTNYLSSKNNEHYYTANLVIFGPGSNIIKNNVIYYKKEYAENGMGTMLEIWFQPFLTHKYDEFYVDPALELIKCLIKSLYYLYGIKPNDNLNIPYRLRNEFNSLEYSELDMIDFLISGGIDYKLLNTNPYWFIDKYFIDTSKNFEKYKNDYEIKIKNNNYIANSIKLYLEQKFKINVKDIWELNLSYFSKEFQIMMPERYNNALNHYYRKEFYVIDYFKNYNINGFKNGQIKTKLPLSKYNKEIINKPELIVNLINQNNTVLMKSNFYGDGLKGNVDNFYSNYIIPYNLNYEHSINYSYLDNVNIEEIEKIPPINDEDIYPYRKNADTFIPVYNITKAKEINTTTPLPVNYLQAQMIDSNDINLSSDFLKVISSKGSLVYSFLNNTMDYLEFIKYDKPIDTDKKYYKWLKAIFRNYSLDITETQEISNQFGDTKIIPWIGRALNILNTNNSFVEEFKNLGPIFLINKKENITIPKIKIDEIPSSMLNFSFKDLSENLFNIYCKNNFYLKKIYYNFLDQWWTQYYSQYFDLICMASKSVLAQEKLIKKLIQKQLRYLMENSNISSTNLILINLTTTNTLRDISNQSQIAINNIDKFFNNAAMCVFENNIYPKFTSFMEQCIKNINKSTKEFILKCTNINETEKSHLIMQNSFSNLDFDFLDIQNMKNLFNLYTELLIKEQTSPYELSLYAFQEQDNNVIGDTSGKNTLVEYPKDIGLVYGINNNAIHLTGANQNIKFTNDYFENGLTNNFSIYFWLRNLNQNTIKSKLIGSKEDNCGWEIYFENNGLVFNIIDSNGNEKNIYLSNISNKSWHYIVISINRLKDQLLIFIDNILVANEDIKEILNIYSSDIISLLSDNNNVYIEGLSVLNKTINSNEILTDYFSDLNNSYIRNFDEEILQYNRTYELFNYVFPEIAINKIEQNNNIYLSNNNENSLNFKPLKFKLLNTNPNKQYVQKWDEVIFSVLDGTEKYLDISIDNNRIQLVDNKNNAKTFIINNDIFISNCLTLTYNNVNVYLSIKNQDYNWVICDLNHDIPKKSYLWILKNI |
| Enzyme Length | 1162 |
| Uniprot Accession Number | Q06366 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Assembles with botulinum neurotoxin type E (BoNT/E) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0 (By similarity). The non-toxic component is necessary to maintain toxicity. {ECO:0000250|UniProtKB:Q45914}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1) |
| Keywords | Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 136,830 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |