| IED ID | IndEnz0002016419 |
| Enzyme Type ID | protease016419 |
| Protein Name |
DNA polymerase subunit gamma-1 EC 2.7.7.7 Mitochondrial DNA polymerase catalytic subunit PolG-alpha |
| Gene Name | POLG MDP1 POLG1 POLGA |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP |
| Enzyme Length | 1239 |
| Uniprot Accession Number | P54098 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| DNA Binding | |
| EC Number | 2.7.7.7 |
| Enzyme Function | FUNCTION: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (52); Chain (1); Compositional bias (1); Helix (39); Natural variant (74); Region (3); Turn (15) |
| Keywords | 3D-structure;DNA replication;DNA-binding;DNA-directed DNA polymerase;Disease variant;Epilepsy;Leigh syndrome;Magnesium;Mitochondrion;Mitochondrion nucleoid;Neurodegeneration;Neuropathy;Nucleotidyltransferase;Primary mitochondrial disease;Progressive external ophthalmoplegia;Reference proteome;Transferase |
| Interact With | Q9UHN1 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (6) |
| Cross Reference PDB | 3IKM; 4ZTU; 4ZTZ; 5C51; 5C52; 5C53; |
| Mapped Pubmed ID | 11687794; 12036482; 12645575; 12686611; 12857740; 14688158; 14729924; 15181170; 15181541; 15356024; 15650046; 15694274; 15981013; 16024923; 16130100; 16263719; 16327803; 16392637; 16464011; 16487403; 16490220; 16534844; 16545482; 16553026; 16574152; 16595552; 16682683; 16896309; 16929381; 16943369; 16957900; 16970152; 16987890; 17005553; 17005554; 17088268; 17209437; 17300808; 17310215; 17339235; 17426723; 17436221; 17650502; 17650503; 17711845; 17725985; 17762861; 17894835; 17923349; 18062861; 18080848; 18193045; 18195151; 18238797; 18270339; 18294203; 18316366; 18321754; 18446447; 18487244; 18500570; 18502641; 18504126; 18546343; 18546365; 18581472; 18585914; 18632724; 18798765; 19010300; 19043662; 19054397; 19189930; 19237606; 19243043; 19251978; 19275594; 19425506; 19435586; 19478085; 19566497; 19578034; 19629138; 19730927; 19752458; 19762913; 19807024; 19813183; 19815814; 19837034; 20138553; 20142534; 20153822; 20176107; 20181062; 20198856; 20220442; 20399836; 20400524; 20438629; 20467438; 20513108; 20522537; 20558295; 20643228; 20685647; 20691285; 20701905; 20734064; 20800603; 20803511; 20818669; 20818731; 20826197; 20869947; 20877624; 20883824; 20927567; 21038416; 21102476; 21138766; 21150319; 21228000; 21357833; 21455106; 21550804; 21670405; 21696159; 21704543; 21778232; 21856450; 21880868; 21953457; 21993618; 22000311; 22084276; 22157815; 22194617; 22276120; 22334187; 22517274; 22528963; 22552686; 22577219; 22580846; 22647225; 22684821; 22711370; 22728862; 22729384; 22963882; 23066759; 23208208; 23250882; 23251356; 23448099; 23525847; 23543747; 23625061; 23673011; 23902751; 23912752; 23921535; 23962909; 24067899; 24122062; 24398692; 24491464; 24508722; 24524965; 24841123; 24943079; 25065347; 25118206; 25210026; 25488682; 25585994; 25660390; 25713120; 25724872; 26056153; 26077851; 26104464; 26124101; 26317126; 26335356; 26446790; 26468652; 26496610; 26735972; 26755490; 26790834; 27143693; 27220468; 27344355; 27538604; 27538665; 27554452; 27748512; 27845271; 27987238; 28069933; 28130605; 28154168; 28206745; 28457473; 28471437; 28905223; 28958595; 29029963; 29109127; 29341116; 29358615; 29920680; 30255931; 30395865; 30423451; 30678510; 30839203; 30968132; 31251605; 31425757; 31799610; 31948198; 32161153; 32191790; 32391929; 32470614; 32958672; 32976988; 33006594; 33087282; 33264635; 33396418; 33413751; 33434755; 33482196; 33579567; 33671400; 33715547; 33847964; 34077112; 34189666; 34285158; 34619353; 34714238; |
| Motif | |
| Gene Encoded By | |
| Mass | 139,562 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:22508 |
| Cross Reference Brenda |