| IED ID | IndEnz0002016420 |
| Enzyme Type ID | protease016420 |
| Protein Name |
DNA polymerase subunit gamma-1 EC 2.7.7.7 Mitochondrial DNA polymerase catalytic subunit PolG-alpha |
| Gene Name | Polg Polg1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MSRLLWKKVAGAKVASGPVPATARWVASSVLDPVPSDGRPPSQMPSSENGQLRLNPLLIQMLSRGLHEQIFGCGGEMPDEAAVQRSVEHLQKHGLWGQPATPLPDVELRLPRLFGGNLDQHFRLLAQKQSLPYLEAAASLLEAQLPPEPKSWAWAEGWTRYGPEGEAEPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSRRLVEERYSWTSQLSPADLIPLGGSTSASSSTKQDGQEQLVVGHNVSFDRAHIREQYLIQDSRMRFLDTMSMHMAISGLSSFQRSLWMGAKQGKHKNPAAHKARAEVPEESQWSSESSSWDWMDISSANNLADVHNLYVGGPPLEKEPRELFVKGSMRDIRENFQDLMQYCARDVWATFEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLTEAQNTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKPASASKLPIEGAGPFGDPMDQEDPGPPSEEEELQRSVTAHNRLQQLRSTTDLLPKRPQHLPGHPGWYRQLCPRLDDPAWAPGPSLLSLQMRVTPKLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTEPPVSPTVESAAVTCPYRAIESLYRKHCLEQGKQQLEPQEVDLAEEFLLTDNSAMWQTVEELGCLDVEAEAKMENSGLSQPLVLPAACAPKSSQPTYHHGNGPYNDVNIPGCWFFKLPHKDGNNYNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRVVTRHPAFDEEGHYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYVLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTAATVGISREHAKIFNYGRIYGAGQSFAERLLMQFNHRLTRQEAAEKAQQMYAVTKGLRRYRLSADGEWLVKQLNLPVDRTEDGWVSLQDLRMIRREASRKSRWKKWEVAAERAWTGGTESEMFNKLESIAMSDTPRTPVLGCCISRALEPSVVQGEFITSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP |
| Enzyme Length | 1218 |
| Uniprot Accession Number | P54099 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| DNA Binding | |
| EC Number | 2.7.7.7 |
| Enzyme Function | FUNCTION: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous gene model prediction (1); Frameshift (1); Region (2); Sequence conflict (14) |
| Keywords | DNA replication;DNA-binding;DNA-directed DNA polymerase;Magnesium;Mitochondrion;Mitochondrion nucleoid;Nucleotidyltransferase;Reference proteome;Transferase |
| Interact With | P09671; P02340 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11031098; 12865426; 14651853; 15164064; 15177179; 15888483; 15895466; 16020738; 16141072; 16172387; 16327803; 16332961; 16619054; 16870370; 17122057; 17310215; 17334366; 17363114; 17662273; 18232733; 18311139; 18365022; 18614015; 18799693; 19171187; 19656491; 19734452; 20403324; 20628647; 21041631; 21109200; 21311045; 21332926; 21368052; 21368114; 21555558; 21664445; 21909133; 22125488; 22225879; 22345551; 22357654; 22743328; 22820179; 22941637; 22962610; 22988144; 23042113; 23090476; 23090637; 23197651; 23418460; 23850316; 23935986; 23965628; 24722488; 24915468; 24945157; 24985350; 25106705; 25378300; 25411424; 25511702; 25575636; 26027936; 26095671; 26124126; 26142281; 26182419; 26212336; 26253742; 26294258; 26464968; 26686024; 26757797; 26876175; 27626666; 27869650; 27986797; 28158260; 28699890; 28768180; 29109127; 29601571; 29660116; 29875308; 29950568; 30040856; 30135585; 30217445; 30240410; 30737259; 30990467; 31344454; 31358769; 31621839; 31992827; 32107436; 32119683; 32669663; 32744417; 33193604; 33315859; 33358867; 33626245; 33956154; 34143518; 9465903; |
| Motif | |
| Gene Encoded By | |
| Mass | 136,758 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:22508 |
| Cross Reference Brenda |