| IED ID | IndEnz0002016442 |
| Enzyme Type ID | protease016442 |
| Protein Name |
Epstein-Barr nuclear antigen 1 EBNA-1 EBV nuclear antigen 1 |
| Gene Name | EBNA1 BKRF1 |
| Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) |
| Taxonomic Lineage | Viruses Duplodnaviria Heunggongvirae Peploviricota Herviviricetes Herpesvirales Herpesviridae Gammaherpesvirinae Lymphocryptovirus Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) |
| Enzyme Sequence | MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAGAGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGAGAGGGAGGAGGAGAGGAGAGGAGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGGAGAGGGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGSGGRGRGGSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPPPGRRPFFHPVGEADYFEYHQEGGPDGEPDVPPGAIEQGPADDPGEGPSTGPRGQGDGGRRKKGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE |
| Enzyme Length | 641 |
| Uniprot Accession Number | P03211 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival. {ECO:0000269|PubMed:15808506, ECO:0000269|PubMed:31941781}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (7); Chain (1); Compositional bias (2); Helix (6); Mutagenesis (2); Region (4) |
| Keywords | 3D-structure;Activator;DNA-binding;Host nucleus;Host-virus interaction;Inhibition of host NF-kappa-B by virus;Inhibition of host adaptive immune response by virus;Inhibition of host proteasome antigen processing by virus;Reference proteome;Transcription;Transcription regulation;Viral immunoevasion;Viral latency;Viral latency initiation and maintenance |
| Interact With | Q13415; Q13416; Q15554; Q93009 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:2161150, ECO:0000269|PubMed:31941781}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (22) |
| Cross Reference PDB | 1B3T; 1VHI; 1YY6; 2FYY; 2FZ3; 3MV7; 3MV8; 3MV9; 4PRA; 4PRE; 4PRI; 4PRP; 5WMF; 5WUM; 5WUN; 6NPI; 6NPM; 6NPP; 6PW2; 6VH6; 7KE3; 7KE5; |
| Mapped Pubmed ID | 12783858; 16474402; 16799465; 17082594; 18946490; 20566715; 24759101; 28104399; 28701406; 30842315; 31142669; 32290261; 34284876; 9020106; 9299613; 9878348; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,427 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |